Nedisertib
Nedisertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against DNA-dependent protein kinase catalytic subunit.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 4 | 1 | — | — | — | 4 | |
| Prostatic neoplasms | D011471 | C61 | 1 | 1 | — | — | — | 1 | |
| Castration-resistant prostatic neoplasms | D064129 | 1 | 1 | — | — | — | 1 | ||
| Cholangiocarcinoma | D018281 | C22.1 | 1 | 1 | — | — | — | 1 | |
| Klatskin tumor | D018285 | EFO_1001005 | 1 | 1 | — | — | — | 1 | |
| Gallbladder neoplasms | D005706 | EFO_0004606 | C23 | 1 | 1 | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | 1 | — | — | — | — | 1 | |
| Gliosarcoma | D018316 | 1 | — | — | — | — | 1 | ||
| Myeloid leukemia acute | D015470 | C92.0 | 1 | — | — | — | — | 1 | |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | — | — | — | — | 1 |
| Endometrioid carcinoma | D018269 | 1 | — | — | — | — | 1 | ||
| Fallopian tube neoplasms | D005185 | 1 | — | — | — | — | 1 | ||
| Acinar cell carcinoma | D018267 | 1 | — | — | — | — | 1 | ||
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 | ||
| Small cell lung carcinoma | D055752 | 1 | — | — | — | — | 1 | ||
| Squamous cell carcinoma of head and neck | D000077195 | 1 | — | — | — | — | 1 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | NEDISERTIB |
| INN | peposertib |
| Description | Nedisertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against DNA-dependent protein kinase catalytic subunit. |
| Classification | Small molecule |
| Drug class | serine/threonine kinase inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc([C@@H](O)c2cc(-c3ncnc4cc(N5CCOCC5)ccc34)c(F)cc2Cl)nn1 |
Identifiers
| PDB | — |
| CAS-ID | 1637542-33-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297629 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | GN429E725A (ChemIDplus, GSRS) |
Target
Agency Approved
PRKDC
PRKDC
Organism
Homo sapiens
Gene name
PRKDC
Gene synonyms
HYRC, HYRC1
NCBI Gene ID
Protein name
DNA-dependent protein kinase catalytic subunit
Protein synonyms
DNA-PK catalytic subunit, DNPK1, hyper-radiosensitivity of murine scid mutation, complementing 1, p460, protein kinase, DNA-activated, catalytic polypeptide
Uniprot ID
Mouse ortholog
Prkdc (19090)
DNA-dependent protein kinase catalytic subunit (Q9Z341)
Alternate
No data
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 121 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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