Permethrin
Nix (permethrin) is a small molecule pharmaceutical. Permethrin was first approved as Nix on 1986-03-31. It is used to treat lice infestations and scabies in the USA.
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Commercial
Trade Name
FDA
EMA
Nix (generic drugs available since 1998-01-23, discontinued: Elimite)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Permethrin
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
NIX | MedTech Products | N-019918 OTC | 1990-05-02 | 1 products, RLD, RS |
Show 2 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
---|---|---|
permethrin | ANDA | 2023-06-07 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
P: Antiparasitic products, insecticides and repellents
— P03: Ectoparasiticides, incl. scabicides, insecticides and repellents
— P03A: Ectoparasiticides, incl. scabicides
— P03AC: Pyrethrines, incl. synthetic compounds, ectoparasiticides, incl. scabicides
— P03AC04: Permethrin
— P03AC54: Permethrin, combinations
HCPCS
No data
Clinical
Clinical Trials
42 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Scabies | D012532 | B86 | 1 | 3 | 7 | 1 | 2 | 14 | |
Pediculus | D010374 | — | 1 | 1 | 1 | 3 | 6 | ||
Lice infestations | D010373 | B85.2 | 1 | — | 4 | 1 | — | 6 | |
Malaria | D008288 | EFO_0001068 | B54 | — | — | 1 | 1 | 2 | 4 |
Trachoma | D014141 | A71 | — | 1 | — | 1 | — | 2 | |
Parasitic diseases | D010272 | EFO_0001067 | B88 | — | — | — | 1 | — | 1 |
Yaws | D015001 | EFO_0007548 | A66 | — | — | — | 1 | — | 1 |
Impetigo | D007169 | EFO_1000714 | L01 | — | — | — | 1 | — | 1 |
Inflammation | D007249 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Lyme disease | D008193 | A69.2 | — | — | 1 | — | — | 1 | |
Infections | D007239 | EFO_0000544 | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Tick bites | D064927 | — | — | — | — | 2 | 2 | ||
Tick-borne diseases | D017282 | — | — | — | — | 1 | 1 | ||
Dengue | D003715 | A90 | — | — | — | — | 1 | 1 | |
Smoking | D012907 | EFO_0003768 | F17 | — | — | — | — | 1 | 1 |
Metabolism | D008660 | GO_0008152 | — | — | — | — | 1 | 1 | |
Pharmacokinetics | D010599 | — | — | — | — | 1 | 1 | ||
Falciparum malaria | D016778 | EFO_0007444 | B50 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common name | PERMETHRIN |
INN | permethrin |
Description | Permethrin is a cyclopropanecarboxylate ester in which the esterifying alcohol is 3-phenoxybenzyl alcohol and the cyclopropane ring is substituted with a 2,2-dichlorovinyl group and with gem-dimethyl groups. It has a role as a pyrethroid ester insecticide, a pyrethroid ester acaricide, an agrochemical, an ectoparasiticide and a scabicide. It is a member of cyclopropanes and a cyclopropanecarboxylate ester. It is functionally related to a 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid. |
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | CC1(C)C(C=C(Cl)Cl)C1C(=O)OCc1cccc(Oc2ccccc2)c1 |
Identifiers
PDB | — |
CAS-ID | 52645-53-1 |
RxCUI | 33199 |
ChEMBL ID | CHEMBL1525 |
ChEBI ID | 34911 |
PubChem CID | 40326 |
DrugBank | DB04930 |
UNII ID | 509F88P9SZ (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,135 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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612 adverse events reported
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