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Perphenazine
Etrafon, Etrafon-a, Etrafon-forte, Triavil, Trilafon (perphenazine) is a small molecule pharmaceutical. Perphenazine was first approved as Triavil 2-25 on 1982-01-01. It is used to treat huntington disease, nausea, psychotic disorders, reye syndrome, and schizophrenia amongst others in the USA. The pharmaceutical is active against D(2) dopamine receptor. In addition, it is known to target 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 7, and histamine H1 receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
nervous system diseasesD009422
hereditary congenital and neonatal diseases and abnormalitiesD009358
nutritional and metabolic diseasesD009750
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Amitriptyline hydrochloride
+
Perphenazine
Tradename
Company
Number
Date
Products
TRIAVIL 2-25New River PharmaceuticalsN-014715 DISCN1982-01-01
1 products
TRIAVIL 4-10New River PharmaceuticalsN-014715 DISCN1982-01-01
1 products
TRIAVIL 2-10New River PharmaceuticalsN-014715 DISCN1982-01-01
1 products
TRIAVIL 4-25New River PharmaceuticalsN-014715 DISCN1982-01-01
1 products
TRIAVIL 4-50New River PharmaceuticalsN-014715 DISCN1982-01-01
1 products
ETRAFON-AMerck Sharp & DohmeN-014713 DISCN1982-01-01
1 products
ETRAFON 2-25Merck Sharp & DohmeN-014713 DISCN1982-01-01
1 products
ETRAFON-FORTEMerck Sharp & DohmeN-014713 DISCN1982-01-01
1 products
ETRAFON 2-10Merck Sharp & DohmeN-014713 DISCN1982-01-01
1 products
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Perphenazine
Tradename
Company
Number
Date
Products
TRILAFONMerck Sharp & DohmeN-010775 DISCN1982-01-01
4 products, RLD
TRILAFONMerck Sharp & DohmeN-011213 DISCN1982-01-01
1 products
TRILAFONMerck Sharp & DohmeN-011294 DISCN1982-01-01
1 products
TRILAFONMerck Sharp & DohmeN-011361 DISCN1982-01-01
1 products
TRILAFONMerck Sharp & DohmeN-011557 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
perphenazineANDA2023-04-10
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
huntington diseaseOrphanet_399D006816G10
nauseaHP_0002018D009325R11.0
psychotic disorders—D011618F20.81
reye syndromeEFO_0007467D012202G93.7
schizophreniaEFO_0000692D012559F20
substance withdrawal syndromeEFO_0005800D013375—
torticollisHP_0000473D014103F45.8
tourette syndromeEFO_0004895D005879F95.2
vomitingHP_0002013D014839R11.1
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AB: Phenothiazines with piperazine structure, antipsychotics
— N05AB03: Perphenazine
HCPCS
Code
Description
J3310
Injection, perphenazine, up to 5 mg
Q0175
Perphenazine, 4 mg, oral, fda approved prescription anti-emetic, for use as a complete therapeutic substitute for an iv anti-emetic at the time of chemotherapy treatment, not to exceed a 48 hour dosage regimen
Clinical
Clinical Trials
62 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I10—3111—15
Essential hypertensionD000075222I10——4138
Type 2 diabetes mellitusD003924EFO_0001360E11——13—4
Heart failureD006333EFO_0003144I5011—113
Chronic renal insufficiencyD051436N18———2—2
Blood pressureD001794EFO_0004325———2—2
DyslipidemiasD050171HP_0003119——11—2
Marfan syndromeD008382Orphanet_558Q87.4——11—2
Myocardial infarctionD009203EFO_0000612I21———1—1
Non-alcoholic fatty liver diseaseD065626EFO_0003095K75.81———1—1
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Atrial fibrillationD001281EFO_0000275I48.0——1—12
Dilated cardiomyopathyD002311EFO_0000407I42.0——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C5012———2
Sedentary behaviorD057185—1———1
AgingD000375GO_0007568R41.81—1———1
Alzheimer diseaseD000544EFO_0000249F03—1———1
Abdominal aortic aneurysmD017544EFO_0004214—1———1
ObesityD009765EFO_0001073E66.9—1———1
Colorectal neoplasmsD015179—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—4———15
Therapeutic equivalencyD0138102————2
Substance-related disordersD019966EFO_0003890F131————1
Post-traumatic stress disordersD013313EFO_0001358F43.11————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Patient participationD010358————11
Coronary diseaseD003327————11
Subdural hematoma chronicD020200————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePERPHENAZINE
INNperphenazine
Description
Perphenazine is a phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10. It has a role as a phenothiazine antipsychotic drug, a dopaminergic antagonist and an antiemetic. It is a member of phenothiazines, a N-alkylpiperazine, a N-(2-hydroxyethyl)piperazine and an organochlorine compound. It derives from a hydride of a 10H-phenothiazine.
Classification
Small molecule
Drug classTypical antipsychotic
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1
Identifiers
PDB—
CAS-ID58-39-9
RxCUI8076
ChEMBL IDCHEMBL567
ChEBI ID8028
PubChem CID4748
DrugBankDB00850
UNII IDFTA7XXY4EZ (ChemIDplus, GSRS)
Target
Agency Approved
DRD2
DRD2
Organism
Homo sapiens
Gene name
DRD2
Gene synonyms
NCBI Gene ID
1813
Protein name
D(2) dopamine receptor
Protein synonyms
Dopamine D2 receptor, seven transmembrane helix receptor
Uniprot ID
Q9UPA9
Mouse ortholog
Drd2 (13489)
D(2) dopamine receptor (Q0VGH9)
Alternate
HTR2A
HTR2A
HTR6
HTR6
HTR2C
HTR2C
HTR7
HTR7
HRH1
HRH1
Organism
Homo sapiens
Gene name
HTR2A
Gene synonyms
HTR2
NCBI Gene ID
3356
Protein name
5-hydroxytryptamine receptor 2A
Protein synonyms
5-HT2 receptor, 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled, serotonin 5-HT-2A receptor, Serotonin receptor 2A
Uniprot ID
Q5T8C0
Mouse ortholog
Htr2a (15558)
5-hydroxytryptamine receptor 2A (P35363)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,091 documents
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Safety
Black-box Warning
Black-box warning for: Perphenazine
Adverse Events
Top Adverse Reactions
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3,632 adverse events reported
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