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Phenelzine
Nardil (phenelzine) is a small molecule pharmaceutical. Phenelzine was first approved as Nardil on 1982-01-01. It is used to treat depressive disorder in the USA. The pharmaceutical is active against amine oxidase [flavin-containing] A and amine oxidase [flavin-containing] B. In addition, it is known to target cytochrome P450 2C8, sodium-dependent noradrenaline transporter, sodium-dependent dopamine transporter, sodium-dependent serotonin transporter, and membrane primary amine oxidase.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
Nardil (generic drugs available since 2010-12-08)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Phenelzine sulfate
Tradename
Company
Number
Date
Products
NARDILPfizerN-011909 RX1982-01-01
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
nardilNew Drug Application2020-12-09
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
depressive disorderEFO_1002014D003866F32.A
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06A: Antidepressants
— N06AF: Monoamine oxidase inhibitors, non-selective
— N06AF03: Phenelzine
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
End stage liver diseaseD058625EFO_1001311K72.121———2
Liver diseasesD008107EFO_0001421K70-K7711———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cocaine-related disordersD019970F141————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Liver transplantationD016031EFO_0010682————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePHENELZINE
INNphenelzine
Description
Phenelzine is a primary amine.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
NNCCc1ccccc1
Identifiers
PDB—
CAS-ID51-71-8
RxCUI8123
ChEMBL IDCHEMBL1089
ChEBI ID8060
PubChem CID3675
DrugBankDB00780
UNII IDO408N561GF (ChemIDplus, GSRS)
Target
Agency Approved
MAOA
MAOA
MAOB
MAOB
Organism
Homo sapiens
Gene name
MAOA
Gene synonyms
NCBI Gene ID
4128
Protein name
amine oxidase [flavin-containing] A
Protein synonyms
MAO-A, Monoamine oxidase type A
Uniprot ID
Q16426
Mouse ortholog
Maoa (17161)
amine oxidase [flavin-containing] A (Q8K0Z8)
Alternate
CYP2C8
CYP2C8
SLC6A2
SLC6A2
SLC6A3
SLC6A3
SLC6A4
SLC6A4
AOC3
AOC3
Organism
Homo sapiens
Gene name
CYP2C8
Gene synonyms
NCBI Gene ID
1558
Protein name
cytochrome P450 2C8
Protein synonyms
CYPIIC8, Cytochrome P450 form 1, Cytochrome P450 IIC2, Cytochrome P450 MP-12, Cytochrome P450 MP-20, cytochrome P450, family 2, subfamily C, polypeptide 8, cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8, flavoprotein-linked monooxygenase, microsomal monooxygenase, P450 form 1, S-mephenytoin 4-hydroxylase, xenobiotic monooxygenase
Uniprot ID
Q9UCZ9
Mouse ortholog
—
—
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,680 documents
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Safety
Black-box Warning
Black-box warning for: Nardil
Adverse Events
Top Adverse Reactions
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2,167 adverse events reported
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