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Phenylbutazone
Azolid, Butazolidin (phenylbutazone) is a small molecule pharmaceutical. Phenylbutazone was first approved as Butazolidin on 1982-01-01. It is used to treat gouty arthritis in the USA. The pharmaceutical is active against prostaglandin G/H synthase 1 and prostaglandin G/H synthase 2. In addition, it is known to target albumin.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
hereditary congenital and neonatal diseases and abnormalitiesD009358
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Phenylbutazone
Tradename
Company
Number
Date
Products
BUTAZOLIDINNovartisN-008319 DISCN1982-01-01
2 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
gouty arthritis—D015210—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AA: Butylpyrazolidines, antiinflammatory and antirheumatic drugs
— M01AA01: Phenylbutazone
— M01B: Antiinflammatory/antirheumatic agents in combination
— M01BA: Antiinflammatory/antirheumatic agents in combination with corticosteroids
— M01BA01: Phenylbutazone and corticosteroids
— M02: Topical products for joint and muscular pain
— M02A: Topical products for joint and muscular pain
— M02AA: Antiinflammatory preparations, non-steroids for topical use
— M02AA01: Phenylbutazone
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePHENYLBUTAZONE
INNphenylbutazone
Description
Phenylbutazone is a member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position. It has a role as a non-narcotic analgesic, a non-steroidal anti-inflammatory drug, an antirheumatic drug, a peripheral nervous system drug, a metabolite and an EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor.
Classification
Small molecule
Drug classanti-inflammatory analgesics (phenylbutazone type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCCC1C(=O)N(c2ccccc2)N(c2ccccc2)C1=O
Identifiers
PDB2BXP
CAS-ID50-33-9
RxCUI8160
ChEMBL IDCHEMBL101
ChEBI ID48574
PubChem CID4781
DrugBankDB00812
UNII IDGN5P7K3T8S (ChemIDplus, GSRS)
Target
Agency Approved
PTGS1
PTGS1
PTGS2
PTGS2
Organism
Homo sapiens
Gene name
PTGS1
Gene synonyms
COX1
NCBI Gene ID
5742
Protein name
prostaglandin G/H synthase 1
Protein synonyms
COX-1, Cyclooxygenase-1, PGH synthase 1, PGHS-1, PHS 1, Prostaglandin H2 synthase 1, Prostaglandin-endoperoxide synthase 1, prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Q5T7T8
Mouse ortholog
Ptgs1 (19224)
prostaglandin G/H synthase 1 (P22437)
Alternate
ALB
ALB
Organism
Homo sapiens
Gene name
ALB
Gene synonyms
NCBI Gene ID
213
Protein name
albumin
Protein synonyms
serum albumin
Uniprot ID
Q9UJZ0
Mouse ortholog
Alb (11657)
albumin (Q8CG74)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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