Pimagedine
Pimagedine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target nitric oxide synthase, inducible.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic retinopathy | D003930 | EFO_0003770 | 1 | — | — | — | — | 1 | |
| Endotoxemia | D019446 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 1 | 1 |
| Asthma | D001249 | EFO_0000270 | J45 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PIMAGEDINE |
| INN | pimagedine |
| Description | Aminoguanidine is a one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor and an EC 1.14.13.39 (nitric oxide synthase) inhibitor. It is a member of guanidines and a one-carbon compound. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | N=C(N)NN |
Identifiers
| PDB | 2NOS |
| CAS-ID | 79-17-4 |
| RxCUI | 1311670 |
| ChEMBL ID | CHEMBL225304 |
| ChEBI ID | 40618 |
| PubChem CID | 2146 |
| DrugBank | DB02533 |
| UNII ID | SCQ4EZQ113 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
NOS2
NOS2
Organism
Homo sapiens
Gene name
NOS2
Gene synonyms
NOS2A
NCBI Gene ID
Protein name
nitric oxide synthase, inducible
Protein synonyms
HEP-NOS, Hepatocyte NOS, Inducible NO synthase, Inducible NOS, iNOS, nitric oxide synthase 2, inducible, nitric oxide synthase 2A (inducible, hepatocytes), nitric oxide synthase, macrophage, NOS type II, NOS, type II, Peptidyl-cysteine S-nitrosylase NOS2
Uniprot ID
Mouse ortholog
Nos2 (18126)
nitric oxide synthase, inducible (P29477)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 423 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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