Tas-116
Tas-116 is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target heat shock protein HSP 90-alpha.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | C80 | 2 | — | — | — | — | 2 | |
| Colorectal neoplasms | D015179 | 1 | — | — | — | — | 1 | ||
| Pancreatic ductal carcinoma | D021441 | 1 | — | — | — | — | 1 | ||
| Non-small-cell lung carcinoma | D002289 | 1 | — | — | — | — | 1 | ||
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 1 | — | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
| Endometrial neoplasms | D016889 | EFO_0004230 | 1 | — | — | — | — | 1 | |
| Sarcoma | D012509 | 1 | — | — | — | — | 1 | ||
| Urinary bladder neoplasms | D001749 | C67 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | TAS-116 |
| INN | pimitespib |
| Description | Tas-116 is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target heat shock protein HSP 90-alpha. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCc1cc(C(N)=O)ccc1-n1nc(C(C)C)c2c(-n3cnc(-c4cnn(C)c4)c3)ccnc21 |
Identifiers
| PDB | — |
| CAS-ID | 1260533-36-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3661115 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | PLO044MUDZ (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
HSP90AA1
HSP90AA1
Organism
Homo sapiens
Gene name
HSP90AA1
Gene synonyms
HSP90A, HSPC1, HSPCA
NCBI Gene ID
Protein name
heat shock protein HSP 90-alpha
Protein synonyms
epididymis luminal secretory protein 52, epididymis secretory sperm binding protein Li 65p, Heat shock 86 kDa, heat shock 90kD protein 1, alpha, heat shock 90kD protein 1, alpha-like 4, heat shock 90kD protein, alpha-like 4, heat shock 90kDa protein 1, alpha, heat shock protein 90kDa alpha (cytosolic), class A member 1, heat shock protein 90kDa alpha family class A member 1, HSP 86, HSP86, LAP-2, Lipopolysaccharide-associated protein 2, LPS-associated protein 2, Renal carcinoma antigen NY-REN-38
Uniprot ID
Mouse ortholog
Hsp90aa1 (15519)
heat shock protein HSP 90-alpha (P07901)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 45 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2 adverse events reported
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