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Pindolol
Viskazide, Visken (pindolol) is a small molecule pharmaceutical. Pindolol was first approved as Visken on 1982-09-03. It is used to treat angina pectoris, hypertension, and myocardial infarction in the USA. The pharmaceutical is active against beta-2 adrenergic receptor and beta-1 adrenergic receptor. In addition, it is known to target 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 1A, and 5-hydroxytryptamine receptor 1B.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Hydrochlorothiazide
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Pindolol
Tradename
Company
Number
Date
Products
VISKAZIDENovartisN-018872 DISCN1987-07-22
2 products
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Pindolol
Tradename
Company
Number
Date
Products
VISKENNovartisN-018285 DISCN1982-09-03
2 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
pindololANDA2023-01-26
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
angina pectorisEFO_0003913D000787I20
hypertensionEFO_0000537D006973I10
myocardial infarctionEFO_0000612D009203I21
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C07: Beta-adrenergic blocking agents
— C07A: Beta blocking agents
— C07AA: Beta blocking agents, non-selective
— C07AA03: Pindolol
— C07C: Beta blocking agents and other diuretics
— C07CA: Beta blocking agents, non-selective, and other diuretics
— C07CA03: Pindolol and other diuretics
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20—11215
Psychotic disordersD011618F20.81—1—2—3
Schizophrenia spectrum and other psychotic disordersD019967———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DementiaD003704F03——1——1
Psychophysiologic disordersD011602F45.9——1——1
DepressionD003863F33.9——1——1
Anxiety disordersD001008EFO_0006788F41.1——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Amyotrophic lateral sclerosisD000690EFO_0000253G12.21—2———2
Intellectual disabilityD008607F73—1———1
Tourette syndromeD005879EFO_0004895F95.2—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PharmacokineticsD0105991————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
TinnitusD014012HP_0000360H93.1————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePINDOLOL
INNpindolol
Description
Pindolol is a member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol. It has a role as a serotonergic antagonist, a beta-adrenergic antagonist, an antihypertensive agent, a vasodilator agent and an antiglaucoma drug. It is a member of indoles and a secondary amine.
Classification
Small molecule
Drug classbeta-blockers (propranolol type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)NCC(O)COc1cccc2[nH]ccc12
Identifiers
PDB—
CAS-ID13523-86-9
RxCUI8332
ChEMBL IDCHEMBL500
ChEBI ID8214
PubChem CID4828
DrugBankDB00960
UNII IDBJ4HF6IU1D (ChemIDplus, GSRS)
Target
Agency Approved
ADRB2
ADRB2
ADRB1
ADRB1
Organism
Homo sapiens
Gene name
ADRB2
Gene synonyms
ADRB2R, B2AR
NCBI Gene ID
154
Protein name
beta-2 adrenergic receptor
Protein synonyms
adrenergic, beta-2-, receptor, surface, adrenoceptor beta 2 surface, Beta-2 adrenoceptor, Beta-2 adrenoreceptor, catecholamine receptor
Uniprot ID
Q9UMZ5
Mouse ortholog
Adrb2 (11555)
beta-2 adrenergic receptor (Q8BH38)
Alternate
HTR2B
HTR2B
HTR2A
HTR2A
HTR1A
HTR1A
HTR1B
HTR1B
Organism
Homo sapiens
Gene name
HTR2B
Gene synonyms
NCBI Gene ID
3357
Protein name
5-hydroxytryptamine receptor 2B
Protein synonyms
5-HT 2B receptor, 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled, 5-hydroxytryptamine 2B receptor, Serotonin receptor 2B
Uniprot ID
Q6P523
Mouse ortholog
Htr2b (15559)
5-hydroxytryptamine receptor 2B (Q9QWS2)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 2,818 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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9,791 adverse events reported
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