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Plevitrexed
Plevitrexed is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target thymidylate synthase.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ovarian neoplasmsD010051EFO_0003893C56—1———1
Fallopian tube neoplasmsD005185—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePLEVITREXED
INNplevitrexed
Description
Plevitrexed is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target thymidylate synthase.
Classification
Small molecule
Drug classantineoplastic thymidylate synthetase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C#CCN(Cc1cc2c(O)nc(C)nc2cc1C)c1ccc(C(=O)N[C@@H](CCc2nnn[nH]2)C(=O)O)c(F)c1
Identifiers
PDB—
CAS-ID153537-73-6
RxCUI—
ChEMBL IDCHEMBL126648
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDL9P2881C3H (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TYMS
TYMS
Organism
Homo sapiens
Gene name
TYMS
Gene synonyms
TS
NCBI Gene ID
7298
Protein name
thymidylate synthase
Protein synonyms
TSase
Uniprot ID
Q8WYK4
Mouse ortholog
Tyms (22171)
thymidylate synthase (P07607)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 11 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4 adverse events reported
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