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Pracinostat
Pracinostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against polyamine deacetylase HDAC10. In addition, it is known to target histone deacetylase 1, histone deacetylase 5, and histone deacetylase 3.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloid leukemia acuteD015470C92.0—11——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myelodysplastic syndromesD009190D4613———4
Myeloproliferative disordersD009196D47.1—1———1
SarcomaD012509—1———1
Prostatic neoplasmsD011471C61—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—3————3
NeoplasmsD009369C802————2
Hematologic neoplasmsD0193371————1
LeukemiaD007938C951————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePRACINOSTAT
INNpracinostat
Description
Pracinostat is a hydroxamic acid that is N-hydroxyacrylamide which is substituted at position 3 by a 2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl group (the E isomer). An orally available pan-histone deacetylase inhibitor with demonstrated activity in the treatment of advanced solid tumours. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor, an antineoplastic agent, an apoptosis inducer and an antimalarial. It is an olefinic compound, a hydroxamic acid, a benzimidazole and a tertiary amino compound.
Classification
Small molecule
Drug classenzyme inhibitors: histone deacetylase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCCc1nc2cc(/C=C/C(=O)NO)ccc2n1CCN(CC)CC
Identifiers
PDB—
CAS-ID929016-96-6
RxCUI—
ChEMBL IDCHEMBL1851943
ChEBI ID—
PubChem CID49855250
DrugBankDB05223
UNII IDGPO2JN4UON (ChemIDplus, GSRS)
Target
Agency Approved
HDAC10
HDAC10
Organism
Homo sapiens
Gene name
HDAC10
Gene synonyms
NCBI Gene ID
83933
Protein name
polyamine deacetylase HDAC10
Protein synonyms
HD10, Histone deacetylase 10
Uniprot ID
Q969S8
Mouse ortholog
Hdac10 (170787)
polyamine deacetylase HDAC10 (Q6P3E7)
Alternate
HDAC1
HDAC1
HDAC5
HDAC5
HDAC3
HDAC3
Organism
Homo sapiens
Gene name
HDAC1
Gene synonyms
RPD3L1
NCBI Gene ID
3065
Protein name
histone deacetylase 1
Protein synonyms
Protein deacetylase HDAC1, Protein decrotonylase HDAC1, reduced potassium dependency, yeast homolog-like 1
Uniprot ID
Q92534
Mouse ortholog
Hdac1 (433759)
histone deacetylase 1 (P97476)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 424 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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20 adverse events reported
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