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Pregnenolone
Pregnenolone is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target glycine receptor subunit beta, nuclear receptor subfamily 1 group I member 2, glycine receptor subunit alpha-1, transient receptor potential cation channel subfamily M member 3, glycine receptor subunit alpha-2, and transient receptor potential cation channel subfamily M member 1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
32 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20131127
Major depressive disorderD003865EFO_0003761F2223—2—6
Psychotic disordersD011618F20.81—2—114
AlcoholismD000437EFO_0003829F10.12——1—3
Bipolar disorderD001714EFO_0000289F30.9———3—3
Substance-related disordersD019966EFO_0003890F13———1—1
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Post-traumatic stress disordersD013313EFO_0001358F43.112——14
Traumatic brain injuriesD000070642S06—2——13
Autistic disorderD001321EFO_0003758F84.0—2———2
Substance withdrawal syndromeD013375EFO_0005800—1———1
Low back painD017116HP_0003419M54.5—1———1
Marijuana abuseD002189EFO_0007191F12—1———1
MenopauseD008593EFO_0003922N9511———1
PerimenopauseD04764811———1
Autism spectrum disorderD000067877F84.0—1———1
FatigueD005221HP_0012378R53.83—1———1
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—2————2
Alcoholic intoxicationD0004351————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePREGNENOLONE
INNpregnenolone
Description
Pregnenolone is a 20-oxo steroid that is pregn-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 20. It has a role as a human metabolite and a mouse metabolite. It is a 20-oxo steroid, a C21-steroid and a 3beta-hydroxy-Delta(5)-steroid. It derives from a hydride of a pregnane.
Classification
Small molecule
Drug classsteroids (not prednisolone derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
Identifiers
PDB—
CAS-ID145-13-1
RxCUI114052
ChEMBL IDCHEMBL253363
ChEBI ID16581
PubChem CID8955
DrugBankDB02789
UNII ID73R90F7MQ8 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
GLRB
GLRB
NR1I2
NR1I2
GLRA1
GLRA1
TRPM3
TRPM3
GLRA2
GLRA2
TRPM1
TRPM1
Organism
Homo sapiens
Gene name
GLRB
Gene synonyms
NCBI Gene ID
2743
Protein name
glycine receptor subunit beta
Protein synonyms
Glycine receptor 58 kDa subunit, glycine receptor, beta subunit
Uniprot ID
P48167
Mouse ortholog
Glrb (14658)
glycine receptor subunit beta (P48168)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,374 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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13 adverse events reported
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