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Prinomastat
Prinomastat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target collagenase 3.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C61——1——1
Lung neoplasmsD008175C34.90——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Central nervous system neoplasmsD016543—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePRINOMASTAT
INNprinomastat
Description
Prinomastat is a hydroxamic acid that is (3S)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide in which the hydrogen attached to the thiomorpholine nitrogen has been replaced by a [4-(pyridin-4-yloxy)phenyl]sulfonyl group. It is a selective inhibitor with of matrix metalloproteinases (MMPs) 2, 3, 9, 13, and 14. It has a role as an antineoplastic agent, a matrix metalloproteinase inhibitor and an EC 3.4.24.35 (gelatinase B) inhibitor. It is a hydroxamic acid, a member of thiomorpholines, a sulfonamide, an aromatic ether and a member of pyridines. It is a conjugate base of a prinomastat(1+).
Classification
Small molecule
Drug classenzyme inhibitors: matrix metalloprotease inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC1(C)SCCN(S(=O)(=O)c2ccc(Oc3ccncc3)cc2)[C@H]1C(=O)NO
Identifiers
PDB—
CAS-ID192329-42-3
RxCUI—
ChEMBL IDCHEMBL75094
ChEBI ID—
PubChem CID466151
DrugBankDB05100
UNII ID10T6626FRK (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
MMP13
MMP13
Organism
Homo sapiens
Gene name
MMP13
Gene synonyms
NCBI Gene ID
4322
Protein name
collagenase 3
Protein synonyms
matrix metalloproteinase 13 (collagenase 3), Matrix metalloproteinase-13, MMP-13
Uniprot ID
Q6NWN6
Mouse ortholog
Mmp13 (17386)
collagenase 3 (P33435)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 363 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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