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Procaine
Achromycin, Novocain, Ravocaine Novocain W/, Tetracyn (procaine) is a small molecule pharmaceutical. Procaine was first approved as Procaine hydrochloride w/ epinephrine on 1982-01-01. It is used to treat pain and substance withdrawal syndrome in the USA. It is known to target ryanodine receptor 1 and ryanodine receptor 2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
psychological phenomenaD011579
mental disordersD001523
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Levonordefrin
+
Procaine hydrochloride
+
Propoxycaine hydrochloride
Tradename
Company
Number
Date
Products
RAVOCAINE AND NOVOCAIN W/ NEO-COBEFRINEastman KodakN-008592 DISCN1982-01-01
1 products
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Norepinephrine bitartrate
+
Procaine hydrochloride
+
Propoxycaine hydrochloride
Tradename
Company
Number
Date
Products
RAVOCAINE AND NOVOCAIN W/ LEVOPHEDEastman KodakN-008592 DISCN1982-01-01
1 products
Hide discontinued
Procaine hydrochloride
+
Tetracycline hydrochloride
Tradename
Company
Number
Date
Products
ACHROMYCINLederle LaboratoriesN-050276 DISCN1982-01-01
2 products
Hide discontinued
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
substance withdrawal syndromeEFO_0005800D013375—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C05: Vasoprotectives
— C05A: Agents for treatment of hemorrhoids and anal fissures for topical use
— C05AD: Local anesthetics for treatment of hemorrhoids and anal fissures for topical use
— C05AD05: Procaine
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01C: Beta-lactam antibacterials, penicillins
— J01CE: Beta-lactamase sensitive penicillins
— J01CE09: Procaine benzylpenicillin
N: Nervous system drugs
— N01: Anesthetics
— N01B: Local anesthetics
— N01BA: Esters of aminobenzoic acid for local anesthesia
— N01BA02: Procaine
— N01BA52: Procaine, combinations
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01H: Local anesthetics, ophthalmologic
— S01HA: Local anesthetics
— S01HA05: Procaine
HCPCS
Code
Description
J0558
Injection, penicillin g benzathine and penicillin g procaine, 100,000 units
J2400
Injection, chloroprocaine hydrochloride, per 30 ml
J2510
Injection, penicillin g procaine, aqueous, up to 600,000 units
Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cardiac arrhythmiasD001145EFO_0004269I49.9——3115
Atrial fibrillationD001281EFO_0000275I48.0——1214
Ventricular tachycardiaD017180I47.2——12—3
TachycardiaD013610HP_0001649R00.0———1—1
Brugada syndromeD053840Orphanet_130I49.8———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 2 diabetes mellitusD003924EFO_0001360E11—21——3
Cardiovascular diseasesD002318EFO_0000319I98——3——3
Heart diseasesD006331EFO_0003777I51.9——3——3
Ventricular fibrillationD014693EFO_0004287I49.01——2——2
Myocardial infarctionD009203EFO_0000612I21——1——1
Heart arrestD006323EFO_0009492I46——1——1
Sudden death cardiacD016757EFO_0004278——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Supraventricular tachycardiaD013617HP_0004755I47.1————11
KeratoconusD007640EFO_0004223H18.6————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePROCAINE
INNprocaine
Description
Procaine is a benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol. It has a role as a local anaesthetic, a central nervous system depressant, a peripheral nervous system drug and a drug allergen. It is a benzoate ester, a substituted aniline and a tertiary amino compound. It is functionally related to a 2-diethylaminoethanol and a 4-aminobenzoic acid. It is a conjugate base of a procaine(1+).
Classification
Small molecule
Drug classlocal anesthetics
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCN(CC)CCOC(=O)c1ccc(N)cc1
Identifiers
PDB—
CAS-ID59-46-1
RxCUI8701
ChEMBL IDCHEMBL569
ChEBI ID8430
PubChem CID4914
DrugBankDB00721
UNII ID4Z8Y51M438 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
RYR1
RYR1
RYR2
RYR2
Organism
Homo sapiens
Gene name
RYR1
Gene synonyms
RYDR
NCBI Gene ID
6261
Protein name
ryanodine receptor 1
Protein synonyms
central core disease of muscle, protein phosphatase 1, regulatory subunit 137, ryanodine receptor 1 (skeletal), sarcoplasmic reticulum calcium release channel, Skeletal muscle calcium release channel, Skeletal muscle ryanodine receptor, Skeletal muscle-type ryanodine receptor, Type 1 ryanodine receptor, type 1-like ryanodine receptor
Uniprot ID
Q9P1U4
Mouse ortholog
Ryr1 (20190)
ryanodine receptor 1 (Q99JF9)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 15,335 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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172 adverse events reported
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