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Proglumide
Proglumide is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cholecystokinin receptor type A.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A02: Drugs for acid related disorders
— A02B: Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)
— A02BX: Other drugs for peptic ulcer and gastro-oesophageal reflux disease (gord) in atc
— A02BX06: Proglumide
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
FibrosisD00535511———1
PainD010146EFO_0003843R5211———1
Healthy volunteers/patients—11———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Liver cirrhosisD008103EFO_0001422K74.01————1
Non-alcoholic fatty liver diseaseD065626EFO_0003095K75.811————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePROGLUMIDE
INNproglumide
Description
Proglumide is a racemate composed of equal amounts of (R)- and (S)-proglumide. A non-selective CCK antagonist that was used primarily for treatment of stomach ulcers, but has been replaced by newer drugs. It has a role as a drug metabolite, a xenobiotic metabolite, a cholinergic antagonist, an anti-ulcer drug, a cholecystokinin antagonist, a gastrointestinal drug, a delta-opioid receptor agonist and an opioid analgesic. It contains a (R)-proglumide and a (S)-proglumide.
Classification
Small molecule
Drug classcholecystokinin (CCK) antagonists, antiulcer, anxiolytic agent
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)c1ccccc1
Identifiers
PDB—
CAS-ID6620-60-6
RxCUI8730
ChEMBL IDCHEMBL316561
ChEBI ID32058
PubChem CID4922
DrugBankDB13431
UNII IDEPL8W5565D (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CCKAR
CCKAR
Organism
Homo sapiens
Gene name
CCKAR
Gene synonyms
CCKRA
NCBI Gene ID
886
Protein name
cholecystokinin receptor type A
Protein synonyms
CCK-A receptor, CCK-AR, CCK1-R, cholecystokinin type-A receptor, Cholecystokinin-1 receptor
Uniprot ID
P32238
Mouse ortholog
Cckar (12425)
cholecystokinin receptor type A (Q9DBV6)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 564 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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