Gt-0918
Gt-0918 is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Therapeutic Areas
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Trade Name
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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Indications
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Agency Specific
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | U07.1 | — | — | 6 | — | 1 | 7 | |
| Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | — | — | 2 | — | 1 | 3 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | — | — | — | — | 1 | 1 | |
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | — | — | — | — | 1 | 1 |
| Alopecia | D000505 | HP_0002293 | L64 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | GT-0918 |
| INN | pruxelutamide |
| Description | Proxalutamide (developmental code name GT-0918) is a nonsteroidal antiandrogen (NSAA) – specifically, a selective high-affinity silent antagonist of the androgen receptor (AR) – which is under development by Suzhou Kintor Pharmaceuticals, inc., a subsidiary of Kintor Pharmaceutical Limited, for the potential treatment of COVID-19, prostate cancer, and breast cancer. It was approved in Paraguay for the treatment of COVID-19 in July 2021, but has not been approved at this time in other countries.
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| Classification | Small molecule |
| Drug class | Nonsteroidal antiandrogen |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2F)C(=S)N1c1ccc(CCCc2ncco2)nc1 |
Identifiers
| PDB | — |
| CAS-ID | 1398046-21-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4594417 |
| ChEBI ID | — |
| PubChem CID | 60194102 |
| DrugBank | DB16065 |
| UNII ID | QX6O64GP40 (ChemIDplus, GSRS) |
Target
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Alternate
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Variants
Clinical Variant
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Trends
PubMed Central
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Additional graphs summarizing 45 documents
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Safety
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Adverse Events
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0 adverse events reported
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