Psilocybine
Psilocybine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
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Trade Name
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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Indications
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Agency Specific
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
121 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Treatment-resistant depressive disorder | D061218 | — | 11 | 2 | — | 1 | 14 | ||
| Depression | D003863 | F33.9 | 3 | 5 | 1 | — | — | 9 | |
| Neoplasms | D009369 | C80 | 2 | 3 | 1 | — | — | 5 | |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | 1 | 3 | 1 | — | — | 5 |
| Professional burnout | D002055 | 1 | — | 1 | — | — | 2 | ||
| Covid-19 | D000086382 | U07.1 | — | — | 1 | — | — | 1 | |
| Caregiver burden | D000084802 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 2 | 12 | — | — | — | 14 |
| Healthy volunteers/patients | — | 12 | 3 | — | — | 1 | 14 | ||
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 9 | — | — | — | 9 |
| Obsessive-compulsive disorder | D009771 | EFO_0004242 | F42 | 5 | 1 | — | — | — | 5 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | 2 | 4 | — | — | — | 5 |
| Anorexia nervosa | D000856 | EFO_0004215 | F50.0 | 2 | 3 | — | — | — | 4 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | 1 | 2 | — | — | — | 3 |
| Demoralization | D000079224 | 1 | 2 | — | — | — | 3 | ||
| Tobacco use disorder | D014029 | F17 | — | 1 | — | — | 1 | 2 | |
| Psychological distress | D000079225 | 2 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine disorders | D008881 | EFO_0003821 | G43 | 2 | — | — | — | — | 2 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | 1 | — | — | — | 1 | 2 |
| Sleep | D012890 | GO_0030431 | 1 | — | — | — | 1 | 2 | |
| Amnesia | D000647 | EFO_1001454 | F44.0 | 1 | — | — | — | — | 1 |
| Distance perception | D004215 | 1 | — | — | — | — | 1 | ||
| Post-traumatic headache | D051298 | G44.3 | 1 | — | — | — | — | 1 | |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | — | — | — | — | 1 |
| Cognitive dysfunction | D060825 | G31.84 | 1 | — | — | — | — | 1 | |
| Grief | D006117 | F43.2 | 1 | — | — | — | — | 1 | |
| Central nervous system vasculitis | D020293 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Creativity | D003405 | — | — | — | — | 1 | 1 | ||
| Nervous system diseases | D009422 | G00-G99 | — | — | — | — | 1 | 1 | |
| Autism spectrum disorder | D000067877 | F84.0 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | PSILOCYBINE |
| INN | psilocybine |
| Description | Psilocybin is a tryptamine alkaloid that is N,N-dimethyltryptamine carrying an additional phosphoryloxy substituent at position 4. The major hallucinogenic alkaloid isolated from Psilocybe mushrooms (also known as Teonanacatl or "magic mushrooms"). It has a role as a hallucinogen, a fungal metabolite, a prodrug and a serotonergic agonist. It is a tryptamine alkaloid, a tertiary amino compound and an organic phosphate. It is functionally related to a psilocin. It is a conjugate acid of a psilocybin(1-). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12 |
Identifiers
| PDB | — |
| CAS-ID | 520-52-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL194378 |
| ChEBI ID | 8614 |
| PubChem CID | 10624 |
| DrugBank | DB11664 |
| UNII ID | 2RV7212BP0 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Trends
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Additional graphs summarizing 47 documents
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Safety
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Adverse Events
Top Adverse Reactions
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35 adverse events reported
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