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Pyridostigmine bromide
Mestinon, Regonol (pyridostigmine bromide) is a small molecule pharmaceutical. Pyridostigmine bromide was first approved as Mestinon on 1982-01-01. It is used to treat drug-induced abnormalities and myasthenia gravis in the USA. It is known to target cholinesterase and acetylcholinesterase.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
nervous system diseasesD009422
hereditary congenital and neonatal diseases and abnormalitiesD009358
immune system diseasesD007154
Trade Name
FDA
EMA
Mestinon, Regonol (generic drugs available since 2003-04-24)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Pyridostigmine bromide
Tradename
Company
Number
Date
Products
MESTINONBausch Health CompaniesN-009829 RX1982-01-01
1 products, RLD, RS
MESTINONBausch Health CompaniesN-009830 RX1982-01-01
1 products, RLD, RS
MESTINONBausch Health CompaniesN-011665 RX1982-01-01
1 products, RLD, RS
MESTINONBausch Health CompaniesN-015193 RX1982-01-01
1 products, RLD, RS
REGONOLSandozN-017398 RX1982-01-01
1 products
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
mestinonNew Drug Application2020-12-02
pyridostigmine bromideANDA2023-05-09
regonolNew Drug Application2022-10-13
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
drug-induced abnormalities—D000014—
myasthenia gravisEFO_0004991D009157G70.0
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N07: Other nervous system drugs in atc
— N07A: Parasympathomimetics
— N07AA: Anticholinesterase parasympathomimetics
— N07AA02: Pyridostigmine
HCPCS
No data
Clinical
Clinical Trials
30 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Postural orthostatic tachycardia syndromeD054972G90.A22—1—5
Myasthenia gravisD009157EFO_0004991G70.0———112
DysphoniaD055154R49.0———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382U07.1—11——1
Sars-cov-2D000086402—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Orthostatic hypotensionD007024I95.113———4
Diabetes mellitusD003920EFO_0000400E08-E1321——13
Spinal muscular atrophies of childhoodD014897Orphanet_83419G12.0—2———2
FibromyalgiaD005356EFO_0005687M79.1—2———2
Parkinson diseaseD010300EFO_0002508G20—2———2
Hiv infectionsD015658EFO_0000764B20—2———2
ConstipationD003248HP_0002019K59.012———2
Spinal muscular atrophyD009134EFO_0008525G12.1—1———1
Chronic fatigue syndromeD015673EFO_0004540G93.31—1———1
Primary dysautonomiasD054969—1———1
Show 11 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pure autonomic failureD0549701————1
Orthostatic intoleranceD0549711————1
Glycogen storage disease type iiD006009Orphanet_365E74.021————1
Job syndromeD007589EFO_0003775D82.41————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetic neuropathiesD003929EFO_1000783————11
Diabetes complicationsD048909————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common namePYRIDOSTIGMINE BROMIDE
INNpyridostigmine bromide
Description
Pyridostigmine is a pyridinium ion.
Classification
Small molecule
Drug classcholinesterase inhibitors (physostigmine type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)C(=O)Oc1ccc[n+](C)c1.[Br-]
Identifiers
PDB—
CAS-ID101-26-8
RxCUI9000
ChEMBL IDCHEMBL812
ChEBI ID—
PubChem CID4991
DrugBankDB00545
UNII IDKVI301NA53 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
BCHE
BCHE
ACHE
ACHE
Organism
Homo sapiens
Gene name
BCHE
Gene synonyms
CHE1
NCBI Gene ID
590
Protein name
cholinesterase
Protein synonyms
Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, cholinesterase (serum) 2, cholinesterase 1, Pseudocholinesterase
Uniprot ID
P06276
Mouse ortholog
Bche (12038)
cholinesterase (Q543J3)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 4,418 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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1,334 adverse events reported
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