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Quinapril
Accupril, Accuretic (quinapril) is a small molecule pharmaceutical. Quinapril was first approved as Accupril on 1991-11-19. It is used to treat diabetic nephropathies, heart failure, hypertension, and left ventricular dysfunction in the USA. It is known to target angiotensin-converting enzyme.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
cardiovascular diseasesD002318
endocrine system diseasesD004700
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Hydrochlorothiazide
+
Quinapril hydrochloride
Tradename
Company
Number
Date
Products
ACCURETICPfizerN-020125 DISCN1999-12-28
3 products, RLD
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Quinapril hydrochloride
Tradename
Company
Number
Date
Products
ACCUPRILPfizerN-019885 DISCN1991-11-19
4 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
accuprilNew Drug Application2020-05-19
accureticNew Drug Application2021-12-06
quinaprilANDA2023-06-08
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
diabetic nephropathiesEFO_0000401D003928—
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
left ventricular dysfunction—D018487—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C09: Agents acting on the renin-angiotensin system
— C09A: Ace inhibitors, plain
— C09AA: Ace inhibitors, plain
— C09AA06: Quinapril
— C09B: Ace inhibitors, combinations
— C09BA: Ace inhibitors and diuretics
— C09BA06: Quinapril and diuretics
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameQUINAPRIL
INNquinapril
Description
Quinapril is a member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the alpha-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, a prodrug and an antihypertensive agent. It is a member of isoquinolines, a dicarboxylic acid monoester, an ethyl ester and a tertiary carboxamide.
Classification
Small molecule
Drug classantihypertensives (ACE inhibitors)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1Cc2ccccc2C[C@H]1C(=O)O
Identifiers
PDB—
CAS-ID85441-61-8
RxCUI35208
ChEMBL IDCHEMBL1592
ChEBI ID8713
PubChem CID54892
DrugBankDB00881
UNII IDRJ84Y44811 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ACE
ACE
Organism
Homo sapiens
Gene name
ACE
Gene synonyms
DCP, DCP1
NCBI Gene ID
1636
Protein name
angiotensin-converting enzyme
Protein synonyms
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1, carboxycathepsin, CD143, CD143 antigen, dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, Kininase II, peptidase P
Uniprot ID
Q7M4L4
Mouse ortholog
Ace (11421)
angiotensin-converting enzyme (P09470)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,794 documents
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Safety
Black-box Warning
Black-box warning for: Accupril, Accuretic
Adverse Events
Top Adverse Reactions
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230 adverse events reported
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