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Quinethazone
Hydromox (quinethazone) is a small molecule pharmaceutical. Quinethazone was first approved as Hydromox on 1982-01-01. It is used to treat edema, heart failure, hypertension, and nephrotic syndrome in the USA.
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Therapeutic Areas
Therapeutic Area
MeSH
urogenital diseasesD000091642
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Quinethazone
Tradename
Company
Number
Date
Products
HYDROMOXLederle LaboratoriesN-013264 DISCN1982-01-01
1 products
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Quinethazone
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Reserpine
Tradename
Company
Number
Date
Products
HYDROMOX RLederle LaboratoriesN-013927 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
edema—D004487R60.9
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
nephrotic syndromeEFO_0004255D009404N04
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C03: Diuretics
— C03B: Low-ceiling diuretics, excl. thiazides
— C03BA: Sulfonamides, low-ceiling diuretics, plain
— C03BA02: Quinethazone
— C03BB: Sulfonamides and potassium in combination, low-ceiling diruetics, excluding thiazides
— C03BB02: Quinethazone and potassium
HCPCS
No data
Clinical
Indications Phases 4
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Indications Phases 3
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Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameQUINETHAZONE
INNquinethazone
Description
Quinethazone is a member of the class of quinazolines that is quinazolin-4-one substituted at positions 2, 6 and 7 by ethyl, sulfamoyl and chloro groups respectively; a thiazide-like diuretic used to treat hypertension. It has a role as an antihypertensive agent and a diuretic.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCC1NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2N1
Identifiers
PDB—
CAS-ID73-49-4
RxCUI59743
ChEMBL IDCHEMBL1532
ChEBI ID8717
PubChem CID6307
DrugBankDB01325
UNII ID455E0S048W (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 58 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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10 adverse events reported
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