Quinaglute, Nuedexta(quinidine)
Cardioquin, Cin-quin, Duraquin, Nuedexta, Quinact, Quinaglute, Quinalan, Quinatime, Quinidex, Quinora (quinidine) is a small molecule pharmaceutical. Quinidine was first approved as Quinaglute on 1982-01-01. It is used to treat atrial fibrillation, atrial flutter, and cardiac arrhythmias in the USA. It has been approved in Europe to treat neurobehavioral manifestations. It is known to target potassium voltage-gated channel subfamily A member 7, potassium voltage-gated channel subfamily A member 5, equilibrative nucleoside transporter 4, potassium voltage-gated channel subfamily H member 5, potassium voltage-gated channel subfamily H member 1, potassium channel subfamily K member 5, potassium channel subfamily T member 1, potassium channel subfamily T member 2, potassium channel subfamily K member 18, potassium channel subfamily K member 6, potassium channel subfamily K member 16, potassium channel subfamily K member 10, potassium voltage-gated channel subfamily A member 4, sodium channel protein type 5 subunit alpha, potassium voltage-gated channel subfamily D member 2, potassium channel subfamily U member 1, and cytochrome P450 2D6.
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Commercial
Trade Name
FDA
EMA
Combinations
Nuedexta (generic drugs available since 1982-01-01)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dextromethorphan hydrobromide
+
Quinidine sulfate
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
NUEDEXTA | Avanir Pharmaceuticals | N-021879 RX | 2010-10-29 | 1 products, RLD, RS |
Quinidine gluconate
Quinidine polygalacturonate
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
CARDIOQUIN | Pharmaceutical Research Associates Inc | N-011642 DISCN | 1982-01-01 | 1 products |
Hide discontinued
Quinidine sulfate
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
QUINIDEX | WYETH PHARMS INC | N-012796 DISCN | 1982-01-01 | 1 products |
Hide discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
---|---|---|
nuedexta | New Drug Application | 2022-11-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
atrial fibrillation | EFO_0000275 | D001281 | I48.0 |
atrial flutter | EFO_0003911 | D001282 | — |
cardiac arrhythmias | EFO_0004269 | D001145 | I49.9 |
Agency Specific
FDA
EMA
No data
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common name | QUINIDINE |
INN | — |
Description | Quinidine is a cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy. It has a role as an alpha-adrenergic antagonist, an antimalarial, an anti-arrhythmia drug, a sodium channel blocker, a muscarinic antagonist, a potassium channel blocker, a P450 inhibitor, an EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor, an EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor and a drug allergen. It derives from a hydride of a cinchonan. |
Classification | Small molecule |
Drug class | — |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12 |
Identifiers
PDB | 4WNU |
CAS-ID | 56-54-2 |
RxCUI | 9068 |
ChEMBL ID | CHEMBL1294 |
ChEBI ID | 28593 |
PubChem CID | 441074 |
DrugBank | DB00908 |
UNII ID | — |
Target
Agency Approved
No data
Alternate
KCNA7
KCNA7
KCNA5
KCNA5
SLC29A4
SLC29A4
KCNH5
KCNH5
KCNH1
KCNH1
KCNK5
KCNK5
KCNT1
KCNT1
KCNT2
KCNT2
KCNK18
KCNK18
KCNK6
KCNK6
KCNK16
KCNK16
KCNK10
KCNK10
KCNA4
KCNA4
SCN5A
SCN5A
KCND2
KCND2
KCNU1
KCNU1
CYP2D6
CYP2D6
Organism
Homo sapiens
Gene name
KCNA7
Gene synonyms
NCBI Gene ID
Protein name
potassium voltage-gated channel subfamily A member 7
Protein synonyms
potassium channel, voltage gated shaker related subfamily A, member 7, potassium voltage-gated channel, shaker-related subfamily, member 7, voltage-dependent potassium channel Kv1.7, voltage-gated potassium channel KCNA7, Voltage-gated potassium channel subunit Kv1.7
Uniprot ID
Mouse ortholog
Kcna7 (16495)
potassium voltage-gated channel subfamily A member 7 (Q17ST2)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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