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Quinaglute, Nuedexta(quinidine polygalacturonate)
Cardioquin, Cin-quin, Duraquin, Nuedexta, Quinact, Quinaglute, Quinalan, Quinatime, Quinidex, Quinora (quinidine polygalacturonate) is a small molecule pharmaceutical. Quinidine polygalacturonate was first approved as Quinaglute on 1982-01-01. It is used to treat atrial fibrillation, atrial flutter, and cardiac arrhythmias in the USA. It has been approved in Europe to treat neurobehavioral manifestations. It is known to target potassium voltage-gated channel subfamily A member 5, potassium voltage-gated channel subfamily H member 5, equilibrative nucleoside transporter 4, potassium voltage-gated channel subfamily A member 7, and potassium voltage-gated channel subfamily H member 1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
behavior and behavior mechanismsD001520
Trade Name
FDA
EMA
Combinations
Nuedexta (generic drugs available since 1982-01-01)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dextromethorphan hydrobromide
+
Quinidine sulfate
Tradename
Company
Number
Date
Products
NUEDEXTAAvanir PharmaceuticalsN-021879 RX2010-10-29
1 products, RLD, RS
Quinidine gluconate
Tradename
Company
Number
Date
Products
QUINAGLUTEBayerN-016647 DISCN1982-01-01
1 products, RLD
QUINIDINE GLUCONATEEli LillyN-007529 DISCN1989-02-10
1 products, RLD
DURAQUINWarner ChilcottN-017917 DISCN1982-01-01
1 products
Hide discontinued
Quinidine polygalacturonate
Tradename
Company
Number
Date
Products
CARDIOQUINPharmaceutical Research Associates IncN-011642 DISCN1982-01-01
1 products
Hide discontinued
Quinidine sulfate
Tradename
Company
Number
Date
Products
QUINIDEXWYETH PHARMS INCN-012796 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
nuedextaNew Drug Application2022-11-30
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
atrial fibrillationEFO_0000275D001281I48.0
atrial flutterEFO_0003911D001282—
cardiac arrhythmiasEFO_0004269D001145I49.9
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Dextromethorphan Hydrobromide / Quinidine Sulfate, Nuedexta, Avanir Pharms
76592822026-08-13U-1093
82274842023-07-17U-1093
ATC Codes
C: Cardiovascular system drugs
— C01: Cardiac therapy drugs
— C01B: Antiarrhythmics, class i and iii
— C01BA: Antiarrhythmics, class ia
— C01BA01: Quinidine
— C01BA51: Quinidine, combinations excl. psycholeptics
— C01BA71: Quinidine, combinations with psycholeptics
HCPCS
No data
Clinical
Clinical Trials
39 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pseudobulbar palsyD020828EFO_1001131——13—4
Alzheimer diseaseD000544EFO_0000249F03—111—3
StrokeD020521EFO_0000712I63.9——11—2
Traumatic brain injuriesD000070642S06——11—2
Atrial fibrillationD001281EFO_0000275I48.0——11—2
DementiaD003704F03———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cardiac arrhythmiasD001145EFO_0004269I49.9—14——4
Amyotrophic lateral sclerosisD000690EFO_0000253G12.21121——3
Cardiovascular diseasesD002318EFO_0000319I98——3——3
Heart diseasesD006331EFO_0003777I51.9——3——3
Parkinson diseaseD010300EFO_0002508G20—11——2
Multiple sclerosisD009103EFO_0003885G35—11——2
Ventricular fibrillationD014693EFO_0004287I49.01——2——2
Huntington diseaseD006816G10——1——1
Myocardial infarctionD009203EFO_0000612I21——1——1
Heart arrestD006323EFO_0009492I46——1——1
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Major depressive disorderD003865EFO_0003761F2211———2
Migraine disordersD008881EFO_0003821G43—1———1
Treatment-resistant depressive disorderD061218—1———1
DyskinesiasD020820G24—1———1
Autistic disorderD001321EFO_0003758F84.0—1———1
NeuralgiaD009437EFO_0009430—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—8————8
Hepatitis bD0065091————1
Non-alcoholic fatty liver diseaseD065626EFO_0003095K75.811————1
ConstipationD003248HP_0002019K59.01————1
Covid-19D000086382U07.11————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameQUINIDINE POLYGALACTURONATE
INN—
Description
Quinidine is a cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy. It has a role as an alpha-adrenergic antagonist, an antimalarial, an anti-arrhythmia drug, a sodium channel blocker, a muscarinic antagonist, a potassium channel blocker, a P450 inhibitor, an EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor, an EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor and a drug allergen. It derives from a hydride of a cinchonan.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12
Identifiers
PDB—
CAS-ID56-54-2
RxCUI9068
ChEMBL IDCHEMBL1201486
ChEBI ID—
PubChem CID441074
DrugBankDB00908
UNII ID—
Target
Agency Approved
No data
Alternate
KCNA5
KCNA5
KCNH5
KCNH5
SLC29A4
SLC29A4
KCNA7
KCNA7
KCNH1
KCNH1
Organism
Homo sapiens
Gene name
KCNA5
Gene synonyms
NCBI Gene ID
3741
Protein name
potassium voltage-gated channel subfamily A member 5
Protein synonyms
cardiac potassium channel, HPCN1, insulinoma and islet potassium channel, potassium channel 1, potassium channel, voltage gated shaker related subfamily A, member 5, potassium voltage-gated channel, shaker-related subfamily, member 5, Voltage-gated potassium channel HK2, voltage-gated potassium channel protein Kv1.5, Voltage-gated potassium channel subunit Kv1.5
Uniprot ID
Q9UDA4
Mouse ortholog
Kcna5 (16493)
potassium voltage-gated channel subfamily A member 5 (Q9Z1R6)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 12,932 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,802 adverse events reported
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