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Quisinostat
Quisinostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target histone deacetylase 2, histone deacetylase 4, histone deacetylase 5, histone deacetylase 7, histone deacetylase 6, histone deacetylase 1, histone deacetylase 3, histone deacetylase 8, histone deacetylase 11, histone deacetylase 9, and polyamine deacetylase HDAC10.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ovarian neoplasmsD010051EFO_0003893C56—1———1
T-cell lymphoma cutaneousD016410C84.A—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD0022891————1
Ovarian epithelial carcinomaD0000772161————1
LeukemiaD007938C951————1
Myelodysplastic syndromesD009190D461————1
NeoplasmsD009369C801————1
LymphomaD008223C85.91————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameQUISINOSTAT
INNquisinostat
Description
N-hydroxy-2-[4-[[(1-methyl-3-indolyl)methylamino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide is a member of indoles.
Classification
Small molecule
Drug classenzyme inhibitors: histone deacetylase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cn1cc(CNCC2CCN(c3ncc(C(=O)NO)cn3)CC2)c2ccccc21
Identifiers
PDB6HSH
CAS-ID875320-29-9
RxCUI—
ChEMBL IDCHEMBL2105763
ChEBI ID—
PubChem CID11538455
DrugBankDB12985
UNII ID9BJ85K1J8S (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HDAC2
HDAC2
HDAC4
HDAC4
HDAC5
HDAC5
HDAC7
HDAC7
HDAC6
HDAC6
HDAC1
HDAC1
HDAC3
HDAC3
HDAC8
HDAC8
HDAC11
HDAC11
HDAC9
HDAC9
HDAC10
HDAC10
Organism
Homo sapiens
Gene name
HDAC2
Gene synonyms
NCBI Gene ID
3066
Protein name
histone deacetylase 2
Protein synonyms
Protein deacylase HDAC2, transcriptional regulator homolog RPD3, YY1-associated factor 1
Uniprot ID
Q92769
Mouse ortholog
Hdac2 (15182)
histone deacetylase 2 (P70288)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 414 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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