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Ralmitaront
Ralmitaront is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target trace amine-associated receptor 1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRALMITARONT
INNralmitaront
Description
Ralmitaront (INN, USAN; developmental code names RG-7906 and RO-6889450) is an investigational antipsychotic drug which is undergoing a clinical trial for the treatment negative symptoms in schizophrenia and schizoaffective disorder. Another clinical trial targeting acute psychotic symptoms of schizophrenia has been terminated due to lack of efficacy. It is a partial agonist of the TAAR1. The medication is being developed by the pharmaceutical company Hoffmann-La Roche. Ralmitaront had completed phase 1 clinical trials.
Classification
Small molecule
Drug classtrace amine associated receptor (TAAR) agonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCc1[nH]nc(C(=O)Nc2ccc([C@H]3CNCCO3)cc2)c1C
Identifiers
PDB—
CAS-ID2133417-13-5
RxCUI—
ChEMBL IDCHEMBL4594376
ChEBI ID—
PubChem CID130429734
DrugBank—
UNII IDQA8MW1Q80P (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TAAR1
TAAR1
Organism
Homo sapiens
Gene name
TAAR1
Gene synonyms
TA1, TAR1, TRAR1
NCBI Gene ID
134864
Protein name
trace amine-associated receptor 1
Protein synonyms
trace amine receptor 1
Uniprot ID
Q96RJ0
Mouse ortholog
Taar1 (111174)
trace amine-associated receptor 1 (Q923Y8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 14 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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