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Rebastinib
Rebastinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target tyrosine-protein kinase Yes and tyrosine-protein kinase ABL1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8022———2
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_00003401————1
Breast neoplasmsD001943EFO_0003869C501————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameREBASTINIB
INNrebastinib
Description
DCC-2036 is a member of the class of ureas that is urea in which one of the nitrogens bears a 3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl substituent, while the other bears a 2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl substituent. It has a role as a tyrosine kinase inhibitor. It is a member of quinolines, a pyridinecarboxamide, a member of pyrazoles, an organofluorine compound and a member of phenylureas.
Classification
Small molecule
Drug classtyrosine kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc4ncccc4c3)c(F)c2)ccn1
Identifiers
PDB—
CAS-ID1020172-07-9
RxCUI—
ChEMBL IDCHEMBL1738757
ChEBI ID62166
PubChem CID25066467
DrugBank—
UNII ID75017Q6I97 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
YES1
YES1
ABL1
ABL1
Organism
Homo sapiens
Gene name
YES1
Gene synonyms
YES
NCBI Gene ID
7525
Protein name
tyrosine-protein kinase Yes
Protein synonyms
cellular yes-1 protein, p61-Yes, Proto-oncogene c-Yes, proto-oncogene tyrosine-protein kinase YES, v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1, Yamaguchi sarcoma oncogene, YES1 proto-oncogene, Src family tyrosine kinase
Uniprot ID
P07947
Mouse ortholog
Yes1 (22612)
tyrosine-protein kinase Yes (Q04736)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 171 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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