Reparixin
Reparixin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target C-X-C chemokine receptor type 2.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | 1 | — | — | 2 |
| Chronic pancreatitis | D050500 | EFO_0000342 | K86.1 | — | 1 | 1 | — | — | 1 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | 1 | 1 | — | — | 1 |
| Viral pneumonia | D011024 | EFO_0007541 | J12.9 | — | — | 1 | — | — | 1 |
| Covid-19 | D000086382 | U07.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 3 | — | — | — | 4 |
| Reperfusion injury | D015427 | — | 3 | — | — | — | 3 | ||
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 1 | — | — | — | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | 1 | — | — | — | 1 |
| Lung transplantation | D016040 | — | 1 | — | — | — | 1 | ||
| Fatigue | D005221 | HP_0012378 | R53.83 | — | 1 | — | — | — | 1 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | REPARIXIN |
| INN | reparixin |
| Description | Reparixin is a monoterpenoid. |
| Classification | Small molecule |
| Drug class | chemokine (C-X-C motif) receptor 2 (CXCR2) modulators |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)Cc1ccc([C@@H](C)C(=O)NS(C)(=O)=O)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 266359-83-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL191413 |
| ChEBI ID | — |
| PubChem CID | 9838712 |
| DrugBank | DB12614 |
| UNII ID | U604E1NB3K (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
CXCR2
CXCR2
Organism
Homo sapiens
Gene name
CXCR2
Gene synonyms
IL8RB
NCBI Gene ID
Protein name
C-X-C chemokine receptor type 2
Protein synonyms
CD182, CDw128b, chemokine (CXC) receptor 2, CXC-R2, CXCR-2, CXCR2 gene for IL8 receptor type B, GRO/MGSA receptor, High affinity interleukin-8 receptor B, IL-8 receptor type 2, IL-8R B, interleukin 8 receptor type 2, interleukin 8 receptor, beta, interleukin-8 receptor type B
Uniprot ID
Mouse ortholog
Cxcr2 (12765)
C-X-C chemokine receptor type 2 (Q53X27)
Variants
Clinical Variant
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 624 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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