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Resatorvid
Resatorvid is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against toll-like receptor 4.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SepsisD018805A41.9——2——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acute-on-chronic liver failureD065290—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRESATORVID
INNresatorvid
Description
Resatorvid (TAK-242) is a drug which acts as a selective antagonist of the receptor TLR4. It has antiinflammatory and neuroprotective effects following brain injury, and also shows activity against some forms of skin cancer and some other cancers, and may show potential as an add-on treatment alongside conventional chemotherapy drugs.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCOC(=O)C1=CCCC[C@H]1S(=O)(=O)Nc1ccc(F)cc1Cl
Identifiers
PDB—
CAS-ID243984-11-4
RxCUI—
ChEMBL IDCHEMBL225157
ChEBI ID—
PubChem CID11703255
DrugBankDB05943
UNII IDH2MZ648C31 (ChemIDplus, GSRS)
Target
Agency Approved
TLR4
TLR4
Organism
Homo sapiens
Gene name
TLR4
Gene synonyms
NCBI Gene ID
7099
Protein name
toll-like receptor 4
Protein synonyms
CD284, homolog of Drosophila toll, hToll, toll like receptor 4 protein
Uniprot ID
O00206
Mouse ortholog
Tlr4 (21898)
toll-like receptor 4 (Q9Z203)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 490 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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