Reserpine

Cam-ap-es, Demi-regroton, Diupres, Diutensen-r, Dralserp, H.r, Hiserpia, Hydrap-es, Hydro-reserp, Hydro-serp, Hydromox, Hydropres, Hydroserpine (r), Metatensin, Naqua, Naquival, Rau-sed, Regroton, Renese-r, Salutensin, Salutensin-demi, Sandril, Ser-a-gen, Ser-ap-es, Serpalan, Serpanray, Serpasil, Serpasil-apresoline, Serpasil-esidrix, Serpate, Serpivite, Unipres (reserpine) is a small molecule pharmaceutical. Reserpine was first approved as Chlorothiazide w/ reserpine on 1982-01-01. It is used to treat dyskinesias, hypertension, and schizophrenia in the USA. The pharmaceutical is active against synaptic vesicular amine transporter. In addition, it is known to target chromaffin granule amine transporter.

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Therapeutic Areas

Therapeutic Area	MeSH
nervous system diseases	D009422
cardiovascular diseases	D002318
signs and symptoms pathological conditions	D013568
mental disorders	D001523

Trade Name

FDA

EMA

No data

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Chlorothiazide

Reserpine

Tradename	Company	Number	Date	Products
DIUPRES-250	Merck KGaA	N-011635 DISCN	1987-08-26	1 products
DIUPRES-500	Merck KGaA	N-011635 DISCN	1987-08-26	1 products

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Chlorthalidone

Reserpine

Tradename	Company	Number	Date	Products
REGROTON	Sanofi	N-015103 DISCN	1982-01-01	1 products
DEMI-REGROTON	Sanofi	N-015103 DISCN	1982-01-01	1 products

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Hydralazine hydrochloride

Hydrochlorothiazide

Reserpine

Tradename	Company	Number	Date	Products
SER-AP-ES	Novartis	N-012193 DISCN	1982-01-01	1 products

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Hydralazine hydrochloride

Reserpine

Tradename	Company	Number	Date	Products
SERPASIL-APRESOLINE	Novartis	N-009296 DISCN	1982-01-01	2 products

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Hydrochlorothiazide

Reserpine

Tradename	Company	Number	Date	Products
HYDROPRES 25	Merck KGaA	N-011958 DISCN	1982-01-01	1 products
HYDROPRES 50	Merck KGaA	N-011958 DISCN	1982-01-01	1 products
SERPASIL-ESIDRIX #1	Novartis	N-011878 DISCN	1982-01-01	1 products
SERPASIL-ESIDRIX #2	Novartis	N-011878 DISCN	1982-01-01	1 products

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Hydroflumethiazide

Reserpine

Tradename	Company	Number	Date	Products
SALUTENSIN	Shire	N-012359 DISCN	1982-01-01	1 products
SALUTENSIN-DEMI	Shire	N-012359 DISCN	1982-01-01	1 products

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Methyclothiazide

Reserpine

Tradename	Company	Number	Date	Products
DIUTENSEN-R	Medpointe Pharm Hlc	N-012708 DISCN	1982-01-01	1 products

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Polythiazide

Reserpine

Tradename	Company	Number	Date	Products
RENESE-R	Mylan	N-013636 DISCN	1982-01-01	1 products

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Quinethazone

Reserpine

Tradename	Company	Number	Date	Products
HYDROMOX R	Lederle Laboratories	N-013927 DISCN	1982-01-01	1 products

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Reserpine

Tradename	Company	Number	Date	Products
HISERPIA	Bowman Pharmaceuticals	N-009631 DISCN	1982-01-01	2 products
RAU-SED	Bristol Myers Squibb	N-009357 DISCN	1982-01-01	4 products
RESERPINE	CM Bundy	N-009663 DISCN	1982-01-01	2 products
RESERPINE	Cycle Pharmaceuticals	N-009859 DISCN	1982-01-01	2 products
RESERPINE	EveryLife Foundation for Rare Diseases	N-010441 DISCN	1982-01-01	4 products
RESERPINE	Impax Laboratories	N-009627 DISCN	1982-01-01	2 products
RESERPINE	Teva	N-011185 DISCN	1982-01-01	2 products
SERPALAN	Lannett	N-010124 DISCN	1982-01-01	2 products
SANDRIL	Eli Lilly	N-009376 DISCN	1982-01-01	2 products
SANDRIL	Eli Lilly	N-010012 DISCN	1982-01-01	1 products
SERPASIL	Novartis	N-009115 DISCN	1982-01-01	4 products
SERPASIL	Novartis	N-009434 DISCN	1982-01-01	1 products
SERPANRAY	Panray Corporation	N-009391 DISCN	1982-01-01	3 products
RESERPINE	Sandoz	N-009838 DISCN	1982-01-01	2 products, RLD
SERPATE	Bausch Health Companies	N-009453 DISCN	1982-01-01	2 products
RESERPINE	Bausch Health Companies	N-009667 DISCN	1982-01-01	2 products
SERPIVITE	Vitarine Pharmaceuticals	N-009645 DISCN	1982-01-01	1 products

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Reserpine

Trichlormethiazide

Tradename	Company	Number	Date	Products
METATENSIN #2	Sanofi	N-012972 DISCN	1982-01-01	1 products
METATENSIN #4	Sanofi	N-012972 DISCN	1982-01-01	1 products
NAQUIVAL	Merck Sharp & Dohme	N-012265 DISCN	1982-01-01	1 products

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Trichlormethiazide

Tradename	Company	Number	Date	Products
NAQUA	Merck Sharp & Dohme	N-012265 DISCN	1982-01-01	2 products

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Labels

FDA

EMA

No data

Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
dyskinesias	—	D020820	G24
hypertension	EFO_0000537	D006973	I10
schizophrenia	EFO_0000692	D012559	F20

Agency Specific

FDA

EMA

No data

Patent Expiration

No data

ATC Codes

C: Cardiovascular system drugs

— C02: Antihypertensives

— C02A: Antiadrenergic agents, centrally acting

— C02AA: Rauwolfia alkaloids, centrally acting antiadrenergic

— C02AA02: Reserpine

— C02AA52: Reserpine, combinations

— C02L: Antihypertensives and diuretics in combination

— C02LA: Rauwolfia alkaloids and diuretics in combination

— C02LA01: Reserpine and diuretics

— C02LA51: Reserpine and diuretics, combinations with other drugs

— C02LA71: Reserpine and diuretics, combinations with psycholeptics

HCPCS

No data

Clinical

Indications Phases 4

No data

Indications Phases 3

No data

Indications Phases 2

No data

Indications Phases 1

No data

Indications Without Phase

No data

Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	RESERPINE
INN	reserpine
Description	Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. It has a role as an antihypertensive agent, a first generation antipsychotic, an adrenergic uptake inhibitor, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, an environmental contaminant, a xenobiotic and a plant metabolite. It is an alkaloid ester, a methyl ester and a yohimban alkaloid. It is functionally related to a reserpic acid.
Classification	Small molecule
Drug class	tricyclic compounds; Rauwolfia alkaloid derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC

Identifiers

PDB	—
CAS-ID	50-55-5
RxCUI	9260
ChEMBL ID	CHEMBL772
ChEBI ID	28487
PubChem CID	5770
DrugBank	DB00206
UNII ID	8B1QWR724A (ChemIDplus, GSRS)

Target

Agency Approved

SLC18A2

Organism

Homo sapiens

Gene name

SLC18A2

Gene synonyms

SVMT, VMAT2

NCBI Gene ID

6571

Protein name

synaptic vesicular amine transporter

Protein synonyms

monoamine neurotransmitter transporter, Monoamine transporter, solute carrier family 18 (vesicular monoamine transporter), member 2, Solute carrier family 18 member 2, synaptic vesicle amine transporter, brain, synaptic vesicle monoamine transporter, brain, VAT2, vesicle monoamine transporter type 2, vesicle monoamine/H+ antiporter, Vesicular amine transporter 2

Uniprot ID

Q9H3P6

Mouse ortholog

Slc18a2 (214084)

synaptic vesicular amine transporter (Q8CC55)

Alternate

SLC18A1

Organism

Homo sapiens

Gene name

SLC18A1

Gene synonyms

VAT1, VMAT1

NCBI Gene ID

6570

Protein name

chromaffin granule amine transporter

Protein synonyms

solute carrier family 18 (vesicular monoamine transporter), member 1, solute carrier family 18 (vesicular monoamine), member 1, Solute carrier family 18 member 1, VAT1, Vesicular amine transporter 1

Uniprot ID

Q9BRE4

Mouse ortholog

Slc18a1 (110877)

chromaffin granule amine transporter (Q8R090)

Variants

Clinical Variant

No data

Financial

No data

Trends

PubMed Central

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Safety

Black-box Warning

No Black-box warning

Adverse Events

Top Adverse Reactions

0 adverse events reported

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