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Resiniferatoxin
Resiniferatoxin is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target potassium voltage-gated channel subfamily C member 1, potassium voltage-gated channel subfamily A member 2, potassium voltage-gated channel subfamily A member 5, transient receptor potential cation channel subfamily V member 1, potassium voltage-gated channel subfamily A member 7, and potassium voltage-gated channel subfamily A member 1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Knee osteoarthritisD020370EFO_0004616M17212——5
Intractable painD010148221——4
Cancer painD000072716G89.3—11——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Palliative careD01016621———2
PainD010146EFO_0003843R52—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Morton neuromaD000070607G57.61————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRESINIFERATOXIN
INNresiniferatoxin
Description
Resiniferatoxin is a heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1). It has a role as a TRPV1 agonist, a plant metabolite, a neurotoxin and an analgesic. It is a diterpenoid, an ortho ester, a tertiary alpha-hydroxy ketone, a member of phenols, a monomethoxybenzene, an organic heteropentacyclic compound, a carboxylic ester and an enone.
Classification
Small molecule
Drug classfluoroquinolone derivatives, nonantibacterial indication (e.g., antineoplastic antibiotics)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C=C(C)[C@]12C[C@@H](C)[C@@]34O[C@](Cc5ccccc5)(O[C@@H]1[C@@H]3C=C(COC(=O)Cc1ccc(O)c(OC)c1)C[C@]1(O)C(=O)C(C)=C[C@H]14)O2
Identifiers
PDB—
CAS-ID57444-62-9
RxCUI—
ChEMBL IDCHEMBL17976
ChEBI ID—
PubChem CID5702546
DrugBankDB06515
UNII IDA5O6P1UL4I (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
KCNC1
KCNC1
KCNA2
KCNA2
KCNA5
KCNA5
TRPV1
TRPV1
KCNA7
KCNA7
KCNA1
KCNA1
Organism
Homo sapiens
Gene name
KCNC1
Gene synonyms
NCBI Gene ID
3746
Protein name
potassium voltage-gated channel subfamily C member 1
Protein synonyms
NGK2, potassium channel, voltage gated Shaw related subfamily C, member 1, voltage-gated potassium channel protein KV3.1, Voltage-gated potassium channel subunit Kv3.1, Voltage-gated potassium channel subunit Kv4
Uniprot ID
P48547
Mouse ortholog
Kcnc1 (16502)
potassium voltage-gated channel subfamily C member 1 (P15388)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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