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Resminostat
Resminostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target histone deacetylase 8, histone deacetylase 6, histone deacetylase 1, and histone deacetylase 3.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
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Patent Expiration
No data
ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Iga glomerulonephritisD005922EFO_0004194———1—1
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Liver neoplasmsD008113EFO_1001513C22.012———2
Sezary syndromeD012751C84.111———2
Mycosis fungoidesD009182C84.011———2
T-cell lymphoma cutaneousD016410C84.A11———2
Colorectal neoplasmsD01517911———1
Hodgkin diseaseD006689C81—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRESMINOSTAT
INNresminostat
Description
Resminostat (4SC-201 or RAS2410) is an orally bioavailable inhibitor of histone deacetylases (HDACs), of which inhibitors are antineoplastic agents.
Classification
Small molecule
Drug classenzyme inhibitors: histone deacetylase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)Cc1ccc(S(=O)(=O)n2ccc(/C=C/C(=O)NO)c2)cc1
Identifiers
PDB6UOB
CAS-ID864814-88-0
RxCUI—
ChEMBL IDCHEMBL4296717
ChEBI ID—
PubChem CID11609955
DrugBankDB12392
UNII ID1578EUB98L (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HDAC8
HDAC8
HDAC6
HDAC6
HDAC1
HDAC1
HDAC3
HDAC3
Organism
Homo sapiens
Gene name
HDAC8
Gene synonyms
HDACL1
NCBI Gene ID
55869
Protein name
histone deacetylase 8
Protein synonyms
histone deacetylase-like 1, Protein deacetylase HDAC8, Protein decrotonylase HDAC8
Uniprot ID
Q9BY41
Mouse ortholog
Hdac8 (70315)
histone deacetylase 8 (Q8VH37)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 307 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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10 adverse events reported
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