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Retosiban
Retosiban is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against oxytocin receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Premature obstetric laborD007752O60613——10
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Premature ejaculationD061686HP_0012876F52.41————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRETOSIBAN
INNretosiban
Description
Retosiban also known as GSK-221,149-A is an oral drug which acts as an oxytocin receptor antagonist. It is being developed by GlaxoSmithKline for the treatment of preterm labour. Retosiban has high affinity for the oxytocin receptor (Ki = 0.65 nM) and has greater than 1400-fold selectivity over the related vasopressin receptors
Classification
Small molecule
Drug classoxytocin antagonists
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(C)n1
Identifiers
PDB—
CAS-ID820957-38-8
RxCUI—
ChEMBL IDCHEMBL429736
ChEBI ID—
PubChem CID96025669
DrugBankDB11818
UNII IDGIE06H28OX (ChemIDplus, GSRS)
Target
Agency Approved
OXTR
OXTR
Organism
Homo sapiens
Gene name
OXTR
Gene synonyms
NCBI Gene ID
5021
Protein name
oxytocin receptor
Protein synonyms
Uniprot ID
Q15071
Mouse ortholog
Oxtr (18430)
oxytocin receptor (P97926)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 63 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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