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Revamilast
Revamilast is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cAMP-specific 3',5'-cyclic phosphodiesterase 4A.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Rheumatoid arthritisD001172EFO_0000685M06.9—1———1
AsthmaD001249EFO_0000270J45—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameREVAMILAST
INNrevamilast
Description
Revamilast is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cAMP-specific 3',5'-cyclic phosphodiesterase 4A.
Classification
Small molecule
Drug classantiasthmatics/antiallergics (not acting primarily as antihistamines): type IV phosphodiesterase
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(Nc1c(Cl)c[n+]([O-])cc1Cl)c1ccc(OC(F)F)c2oc3ccncc3c12
Identifiers
PDB—
CAS-ID893555-90-3
RxCUI—
ChEMBL IDCHEMBL4297527
ChEBI ID—
PubChem CID—
DrugBank—
UNII ID30LE65637T (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
PDE4A
PDE4A
Organism
Homo sapiens
Gene name
PDE4A
Gene synonyms
DPDE2
NCBI Gene ID
5141
Protein name
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Protein synonyms
DPDE2, PDE46, phosphodiesterase 4A, cAMP-specific (dunce, phosphodiesterase E2 dunce homolog, Drosophila, phosphodiesterase isozyme 4
Uniprot ID
Q9H3H2
Mouse ortholog
Pde4a (18577)
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (O89084)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 9 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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