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Ricolinostat
Ricolinostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target histone deacetylase 6, histone deacetylase 3, histone deacetylase 2, histone deacetylase 1, and histone deacetylase 8.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple myelomaD009101C90.042———4
Diabetic neuropathiesD003929EFO_1000783—1———1
LymphomaD008223C85.911———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Peripheral nervous system diseasesD010523G642————2
Ovarian neoplasmsD010051EFO_0003893C561————1
Fallopian tube neoplasmsD0051851————1
B-cell chronic lymphocytic leukemiaD015451C91.11————1
Breast neoplasmsD001943EFO_0003869C501————1
Healthy volunteers/patients—1————1
CholangiocarcinomaD018281C22.11————1
Klatskin tumorD018285EFO_10010051————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRICOLINOSTAT
INNricolinostat
Description
N-[7-(hydroxyamino)-7-oxoheptyl]-2-(N-phenylanilino)-5-pyrimidinecarboxamide is a pyrimidinecarboxylic acid.
Classification
Small molecule
Drug classenzyme inhibitors: histone deacetylase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(CCCCCCNC(=O)c1cnc(N(c2ccccc2)c2ccccc2)nc1)NO
Identifiers
PDB—
CAS-ID1316214-52-4
RxCUI—
ChEMBL IDCHEMBL2364628
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDWKT909C62B (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HDAC6
HDAC6
HDAC3
HDAC3
HDAC2
HDAC2
HDAC1
HDAC1
HDAC8
HDAC8
Organism
Homo sapiens
Gene name
HDAC6
Gene synonyms
KIAA0901
NCBI Gene ID
10013
Protein name
histone deacetylase 6
Protein synonyms
protein phosphatase 1, regulatory subunit 90, Tubulin-lysine deacetylase HDAC6
Uniprot ID
Q9UBN7
Mouse ortholog
Hdac6 (15185)
histone deacetylase 6 (Q9Z2V5)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 475 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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75 adverse events reported
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