Rilapladib
Rilapladib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against platelet-activating factor acetylhydrolase.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | 3 | 1 | — | — | — | 4 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 1 | — | — | — | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | RILAPLADIB |
| INN | rilapladib |
| Description | Rilapladib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against platelet-activating factor acetylhydrolase. |
| Classification | Small molecule |
| Drug class | phospholipase A2 inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COCCN1CCC(N(Cc2ccc(-c3ccc(C(F)(F)F)cc3)cc2)C(=O)Cn2c(SCc3cccc(F)c3F)cc(=O)c3ccccc32)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 194085-75-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2104981 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | O14CWE893Z (ChemIDplus, GSRS) |
Target
Agency Approved
PLA2G7
PLA2G7
Organism
Homo sapiens
Gene name
PLA2G7
Gene synonyms
PAFAH
NCBI Gene ID
Protein name
platelet-activating factor acetylhydrolase
Protein synonyms
1-alkyl-2-acetylglycerophosphocholine esterase, 2-acetyl-1-alkylglycerophosphocholine esterase, Group-VIIA phospholipase A2, gVIIA-PLA2, LDL-associated phospholipase A2, LDL-PLA(2), lipoprotein-associated phospholipase A2, PAF 2-acylhydrolase, PAF acetylhydrolase, phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Uniprot ID
Mouse ortholog
Pla2g7 (27226)
platelet-activating factor acetylhydrolase (Q921T4)
Alternate
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Variants
Clinical Variant
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 55 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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