Qinlock(ripretinib)
Qinlock (ripretinib) is a small molecule pharmaceutical. Ripretinib was first approved as Qinlock on 2020-05-15. It is used to treat gastrointestinal stromal tumors in the USA. It has been approved in Europe to treat gastrointestinal stromal tumors. It is known to target mast/stem cell growth factor receptor Kit.
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FDA Novel Drug Approvals 2020
Commercial
Trade Name
FDA
EMA
Qinlock
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ripretinib
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
QINLOCK | Deciphera Pharmaceuticals | N-213973 RX | 2020-05-15 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
---|---|---|
qinlock | New Drug Application | 2020-10-08 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
gastrointestinal stromal tumors | EFO_0000505 | D046152 | C49.A |
Agency Specific
FDA
EMA
Expiration | Code | ||
---|---|---|---|
RIPRETINIB, QINLOCK, DECIPHERA PHARMS | |||
2027-05-15 | ODE-298 | ||
2025-05-15 | NCE |
Patent Expiration
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Ripretinib, Qinlock, Deciphera Pharms | |||
11185535 | 2040-12-30 | DP | |
11395818 | 2040-12-30 | DP | |
11576903 | 2040-12-30 | DP | |
11612591 | 2040-12-30 | DP | |
10966966 | 2040-08-12 | U-3153 | |
11266635 | 2040-08-12 | U-3330 | |
11344536 | 2040-08-12 | U-3381 | |
11426390 | 2040-08-12 | U-3416 | |
11433056 | 2040-08-12 | U-3423 | |
11529336 | 2040-08-12 | U-3382 | |
11534432 | 2040-08-12 | U-3442 | |
11576904 | 2040-08-12 | U-3537 | |
RE48731 | 2032-06-07 | U-3219 | |
8461179 | 2032-06-07 | DS, DP | |
8188113 | 2030-07-27 | DS, DP |
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 3 | 3 | 3 | — | 3 | 11 |
Indications Phases 2
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common name | RIPRETINIB |
INN | ripretinib |
Description | Ripretinib, sold under the brand name Qinlock, is a medication for the treatment of adults with advanced gastrointestinal stromal tumor (GIST), a type of tumor that originates in the gastrointestinal tract. It is taken by mouth. Ripretinib inhibits the activity of the kinases KIT and PDGFRA, which helps keep cancer cells from growing.
|
Classification | Small molecule |
Drug class | retinol derivatives; tyrosine kinase inhibitors |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | CCn1c(=O)c(-c2cc(NC(=O)Nc3ccccc3)c(F)cc2Br)cc2cnc(NC)cc21 |
Identifiers
PDB | — |
CAS-ID | 1442472-39-0 |
RxCUI | — |
ChEMBL ID | CHEMBL4216467 |
ChEBI ID | — |
PubChem CID | 71584930 |
DrugBank | DB14840 |
UNII ID | 9XW757O13D (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KIT
KIT
Organism
Homo sapiens
Gene name
KIT
Gene synonyms
SCFR
NCBI Gene ID
Protein name
mast/stem cell growth factor receptor Kit
Protein synonyms
c-Kit protooncogene, CD117, p145 c-kit, PBT, Piebald trait protein, Proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, Tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Uniprot ID
Mouse ortholog
Kit (16590)
mast/stem cell growth factor receptor Kit (Q8C8K9)
Variants
Clinical Variant
No data
Financial
Qinlock - Zai Lab
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 285 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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