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Rolipram
Rolipram is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cAMP-specific 3',5'-cyclic phosphodiesterase 4C, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, and cAMP-specific 3',5'-cyclic phosphodiesterase 4A.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Mock data
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Nervous system diseasesD009422G00-G9911———1
Multiple sclerosisD009103EFO_0003885G35—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—2————2
Major depressive disorderD003865EFO_0003761F221————1
Huntington diseaseD006816G101————1
DepressionD003863F33.91————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameROLIPRAM
INNrolipram
Description
Rolipram is a member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor. It has a role as an antidepressant and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1ccc(C2CNC(=O)C2)cc1OC1CCCC1
Identifiers
PDB1XN0
CAS-ID61413-54-5
RxCUI—
ChEMBL IDCHEMBL63
ChEBI ID104872
PubChem CID5092
DrugBankDB01954
UNII IDK676NL63N7 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
PDE4C
PDE4C
PDE4B
PDE4B
PDE4D
PDE4D
PDE4A
PDE4A
Organism
Homo sapiens
Gene name
PDE4C
Gene synonyms
DPDE1
NCBI Gene ID
5143
Protein name
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Protein synonyms
DPDE1, dunce-like phosphodiesterase E1, PDE21, phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
Uniprot ID
Q9UPJ6
Mouse ortholog
Pde4c (110385)
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Q8K0P4)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,616 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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