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Ropinirole
Requip (ropinirole) is a small molecule pharmaceutical. Ropinirole was first approved as Requip on 1997-09-19. It is used to treat parkinson disease in the USA. The pharmaceutical is active against D(3) dopamine receptor and D(2) dopamine receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ropinirole hydrochloride
Tradename
Company
Number
Date
Products
REQUIPGSKN-020658 DISCN1997-09-19
7 products, RLD
REQUIP XLGSKN-022008 DISCN2008-06-13
6 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
requipNew Drug Application2011-12-27
ropiniroleANDA2023-03-29
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
parkinson diseaseEFO_0002508D010300G20
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N04: Anti-parkinson drugs
— N04B: Dopaminergic agents
— N04BC: Dopamine agonists
— N04BC04: Ropinirole
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Intraocular pressureD007429———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Dry eye syndromesD015352H04.12——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameROPINIROLE
INNropinirole
Description
Ropinirole is a member of indolones and a tertiary amine. It has a role as a dopamine agonist, an antiparkinson drug, a central nervous system drug and an antidyskinesia agent.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCN(CCC)CCc1cccc2c1CC(=O)N2
Identifiers
PDB—
CAS-ID91374-21-9
RxCUI72302
ChEMBL IDCHEMBL589
ChEBI ID8888
PubChem CID5095
DrugBankDB00268
UNII ID030PYR8953 (ChemIDplus, GSRS)
Target
Agency Approved
DRD3
DRD3
DRD2
DRD2
Organism
Homo sapiens
Gene name
DRD3
Gene synonyms
NCBI Gene ID
1814
Protein name
D(3) dopamine receptor
Protein synonyms
Dopamine D3 receptor, essential tremor 1
Uniprot ID
Q4VBM8
Mouse ortholog
Drd3 (13490)
D(3) dopamine receptor (P30728)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,523 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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94 adverse events reported
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