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Rupatadine
Rupatadine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against histamine H1 receptor. In addition, it is known to target platelet-activating factor receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AX: Other antihistamines for systemic use in atc
— R06AX28: Rupatadine
HCPCS
No data
Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1——1—2
Allergic rhinitisD065631J30.9———1—1
HypersensitivityD006967EFO_0003785T78.40———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
UrticariaD014581EFO_0005531L50—11——2
Rheumatoid arthritisD001172EFO_0000685M06.9——1——1
Chronic urticariaD000080223L50.8——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameRUPATADINE
INNrupatadine
Description
Rupatadine is a benzocycloheptapyridine.
Classification
Small molecule
Drug classtricyclic histaminic-H1 receptor antagonists, loratadine derivatives (formerly-tadine)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cncc(CN2CCC(=C3c4ccc(Cl)cc4CCc4cccnc43)CC2)c1
Identifiers
PDB—
CAS-ID158876-82-5
RxCUI—
ChEMBL IDCHEMBL91397
ChEBI ID—
PubChem CID133017
DrugBankDB11614
UNII ID2AE8M83G3E (ChemIDplus, GSRS)
Target
Agency Approved
HRH1
HRH1
Organism
Homo sapiens
Gene name
HRH1
Gene synonyms
NCBI Gene ID
3269
Protein name
histamine H1 receptor
Protein synonyms
histamine receptor, subclass H1
Uniprot ID
Q6P9E5
Mouse ortholog
Hrh1 (15465)
histamine H1 receptor (Q91XN3)
Alternate
PTAFR
PTAFR
Organism
Homo sapiens
Gene name
PTAFR
Gene synonyms
PAFR
NCBI Gene ID
5724
Protein name
platelet-activating factor receptor
Protein synonyms
PAF-R
Uniprot ID
P25105
Mouse ortholog
Ptafr (19204)
platelet-activating factor receptor (Q8C017)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 461 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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265 adverse events reported
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