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Secretin
Chirhostim (secretin) is a protein pharmaceutical. Secretin was first approved as Secretin-ferring on 1982-01-01. The pharmaceutical is active against secretin receptor. In addition, it is known to target pituitary adenylate cyclase-activating polypeptide type I receptor, vasoactive intestinal polypeptide receptor 2, and vasoactive intestinal polypeptide receptor 1.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Chirhostim
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Secretin
Tradename
Company
Number
Date
Products
SECRETIN-FERRINGFerring PharmaceuticalsN-018290 DISCN1982-01-01
1 products
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Secretin synthetic human
Tradename
Company
Number
Date
Products
CHIRHOSTIMChiRhoClinN-021256 RX2004-04-09
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
chirhostim chirhostim 40New Drug Application2019-10-30
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
V: Various drug classes in atc
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CK: Pancreatic function test diagnostic agents
— V04CK01: Secretin
HCPCS
Code
Description
J2850
Injection, secretin, synthetic, human, 1 microgram
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSECRETIN
INNsecretin
Description
Secretin human is a polypeptide.
Classification
Peptide
Drug classretinol derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H](C(N)=O)C(C)C
Identifiers
PDB—
CAS-ID1393-25-5
RxCUI606396
ChEMBL IDCHEMBL3039582
ChEBI ID—
PubChem CID71306891
DrugBankDB09532
UNII ID88C55N56UU (ChemIDplus, GSRS)
Target
Agency Approved
SCTR
SCTR
Organism
Homo sapiens
Gene name
SCTR
Gene synonyms
NCBI Gene ID
6344
Protein name
secretin receptor
Protein synonyms
pancreatic secretin receptor
Uniprot ID
Q53T00
Mouse ortholog
Sctr (319229)
secretin receptor (Q5FWI2)
Alternate
ADCYAP1R1
ADCYAP1R1
VIPR2
VIPR2
VIPR1
VIPR1
Organism
Homo sapiens
Gene name
ADCYAP1R1
Gene synonyms
NCBI Gene ID
117
Protein name
pituitary adenylate cyclase-activating polypeptide type I receptor
Protein synonyms
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I, PACAP receptor 1, PACAP type I receptor, PACAP-R1, pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop, pituitary adenylate cyclase-activating polypeptide type 1 receptor
Uniprot ID
Q17S10
Mouse ortholog
Adcyap1r1 (11517)
pituitary adenylate cyclase-activating polypeptide type I receptor (P70205)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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80 adverse events reported
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