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Selonsertib
Selonsertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against mitogen-activated protein kinase kinase kinase 5.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Alcoholic hepatitisD006519EFO_1001345K70.111———2
Diabetic nephropathiesD003928EFO_000040111———2
Pulmonary arterial hypertensionD000081029—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSELONSERTIB
INNselonsertib
Description
Selonsertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against mitogen-activated protein kinase kinase kinase 5.
Classification
Small molecule
Drug classserine/threonine kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
Identifiers
PDB—
CAS-ID1448428-04-3
RxCUI—
ChEMBL IDCHEMBL3916717
ChEBI ID—
PubChem CID—
DrugBank—
UNII IDNS3988A2TC (ChemIDplus, GSRS)
Target
Agency Approved
MAP3K5
MAP3K5
Organism
Homo sapiens
Gene name
MAP3K5
Gene synonyms
ASK1, MAPKKK5, MEKK5
NCBI Gene ID
4217
Protein name
mitogen-activated protein kinase kinase kinase 5
Protein synonyms
Apoptosis signal-regulating kinase 1, ASK-1, MAP/ERK kinase kinase 5, MAPK/ERK kinase kinase 5, MEK kinase 5, MEKK 5
Uniprot ID
Q99683
Mouse ortholog
Map3k5 (26408)
mitogen-activated protein kinase kinase kinase 5 (Q14AY5)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 613 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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