Senicapoc
Senicapoc is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against intermediate conductance calcium-activated potassium channel protein 4.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
8 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | 1 | 2 | — | — | 3 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Exercise-induced asthma | D001250 | J45.990 | — | 1 | — | — | — | 1 | |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | — | — | — | 1 |
| Cognitive dysfunction | D060825 | G31.84 | — | 1 | — | — | — | 1 | |
| Covid-19 | D000086382 | U07.1 | — | 1 | — | — | — | 1 | |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 1 | — | — | — | 1 |
| Asthma | D001249 | EFO_0000270 | J45 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | SENICAPOC |
| INN | senicapoc |
| Description | Senicapoc (ICA-17043) is a Gardos channel blocker.
|
| Classification | Small molecule |
| Drug class | agonists of the Gardos channel, or the calcium activated potassium channel of intermediate conductance |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 289656-45-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL405821 |
| ChEBI ID | — |
| PubChem CID | 216327 |
| DrugBank | DB06280 |
| UNII ID | TS6G201A6Q (ChemIDplus, GSRS) |
Target
Agency Approved
KCNN4
KCNN4
Organism
Homo sapiens
Gene name
KCNN4
Gene synonyms
IK1, IKCA1, KCA4, SK4
NCBI Gene ID
Protein name
intermediate conductance calcium-activated potassium channel protein 4
Protein synonyms
IK1, IKCa1, intermediate-conductance Ca2+-activated K+ channel, KCa3.1, KCa3.1, KCa4, potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel, Putative Gardos channel, SKCa 4, SKCa4, small conductance calcium-activated potassium channel 4
Uniprot ID
Mouse ortholog
Kcnn4 (16534)
intermediate conductance calcium-activated potassium channel protein 4 (Q9CY39)
Alternate
No data
Variants
Clinical Variant
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 277 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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