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Sertindole
Sertindole is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against D(4) dopamine receptor, 5-hydroxytryptamine receptor 2A, D(3) dopamine receptor, 5-hydroxytryptamine receptor 2C, and D(2) dopamine receptor. In addition, it is known to target 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1F, 5-hydroxytryptamine receptor 1D, histamine H1 receptor, and 5-hydroxytryptamine receptor 1A.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
schizophreniaEFO_0000692D012559F20
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AE: Indole derivatives, antipsychotic
— N05AE03: Sertindole
HCPCS
No data
Clinical
Clinical Trials
15 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20——64313
Psychotic disordersD011618F20.81———1—1
Schizophrenia spectrum and other psychotic disordersD019967———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DementiaD003704F03——1——1
Psychophysiologic disordersD011602F45.9——1——1
DepressionD003863F33.9——1——1
Anxiety disordersD001008EFO_0006788F41.1——1——1
CognitionD003071EFO_0003925——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bipolar disorderD001714EFO_0000289F30.9————11
Healthy volunteers/patients—————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSERTINDOLE
INNsertindole
Description
Sertindole is a phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-oxoimidazolidin-1-yl)ethyl group. It has a role as a serotonergic antagonist, an alpha-adrenergic antagonist, a H1-receptor antagonist and a second generation antipsychotic. It is a phenylindole, an organofluorine compound, an organochlorine compound, a heteroarylpiperidine and an imidazolidinone.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C1NCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1
Identifiers
PDB—
CAS-ID106516-24-9
RxCUI41996
ChEMBL IDCHEMBL12713
ChEBI ID9122
PubChem CID60149
DrugBankDB06144
UNII IDGVV4Z879SP (ChemIDplus, GSRS)
Target
Agency Approved
DRD4
DRD4
HTR2A
HTR2A
DRD3
DRD3
HTR2C
HTR2C
DRD2
DRD2
Organism
Homo sapiens
Gene name
DRD4
Gene synonyms
NCBI Gene ID
1815
Protein name
D(4) dopamine receptor
Protein synonyms
D(2C) dopamine receptor, Dopamine D4 receptor, seven transmembrane helix receptor
Uniprot ID
Q8NGM5
Mouse ortholog
Drd4 (13491)
D(4) dopamine receptor (Q8BXS4)
Alternate
HTR1E
HTR1E
HTR1B
HTR1B
HTR1F
HTR1F
HTR1D
HTR1D
HRH1
HRH1
HTR1A
HTR1A
Organism
Homo sapiens
Gene name
HTR1E
Gene synonyms
NCBI Gene ID
3354
Protein name
5-hydroxytryptamine receptor 1E
Protein synonyms
5-HT-1E, 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled, S31, Serotonin receptor 1E
Uniprot ID
Q9P1Y1
Mouse ortholog
—
—
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,211 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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83 adverse events reported
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