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Setanaxib
Setanaxib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against NADPH oxidase 4 and NADPH oxidase 1. In addition, it is known to target cytochrome b-245 heavy chain and NADPH oxidase 5.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
7 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Biliary liver cirrhosisD008105K74.3—21——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Idiopathic pulmonary fibrosisD054990J84.112—1———1
Type 2 diabetes mellitusD003924EFO_0001360E11—1———1
Squamous cell carcinoma of head and neckD000077195—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSETANAXIB
INNsetanaxib
Description
Setanaxib (development code GKT-831) is an experimental orally bioavailable dual inhibitor of NADPH oxidase isoforms NOX4 and NOX1. Setanaxib is a member of the pyrazolopyridine dione chemical series. The compound is the only specific NOX inhibitor that has entered into clinical trials.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)c1cccc(-c2c3c(=O)n(-c4ccccc4Cl)[nH]c3cc(=O)n2C)c1
Identifiers
PDB—
CAS-ID1218942-37-0
RxCUI—
ChEMBL IDCHEMBL4303187
ChEBI ID—
PubChem CID58496428
DrugBank—
UNII ID45II35329V (ChemIDplus, GSRS)
Target
Agency Approved
NOX4
NOX4
NOX1
NOX1
Organism
Homo sapiens
Gene name
NOX4
Gene synonyms
RENOX
NCBI Gene ID
50507
Protein name
NADPH oxidase 4
Protein synonyms
Kidney oxidase-1, Kidney superoxide-producing NADPH oxidase, KOX-1, Renal NAD(P)H-oxidase
Uniprot ID
Q9NPH5
Mouse ortholog
Nox4 (50490)
NADPH oxidase 4 (Q9JHI8)
Alternate
CYBB
CYBB
NOX5
NOX5
Organism
Homo sapiens
Gene name
CYBB
Gene synonyms
NOX2
NCBI Gene ID
1536
Protein name
cytochrome b-245 heavy chain
Protein synonyms
CGD91-phox, Cytochrome b(558) subunit beta, cytochrome b-245 beta polypeptide, Cytochrome b558 subunit beta, gp91-1, gp91-phox, Heme-binding membrane glycoprotein gp91phox, NADPH oxidase 2, Neutrophil cytochrome b 91 kDa polypeptide, p22 phagocyte B-cytochrome, Superoxide-generating NADPH oxidase heavy chain subunit
Uniprot ID
Q2PP16
Mouse ortholog
Cybb (13058)
cytochrome b-245 heavy chain (Q61093)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 110 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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