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Sevoflurane
Ultane (sevoflurane) is a small molecule pharmaceutical. Sevoflurane was first approved as Ultane on 1995-06-07. It is used to treat pain in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Ultane (generic drugs available since 2002-07-02)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Sevoflurane
Tradename
Company
Number
Date
Products
ULTANEAbbVieN-020478 RX1995-06-07
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
sevofluraneANDA2023-05-31
ultaneNew Drug Application2022-08-18
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N01: Anesthetics
— N01A: Anesthetics, general
— N01AB: Halogenated hydrocarbons, general anesthetics
— N01AB08: Sevoflurane
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Left ventricular dysfunctionD018487——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382U07.1—1———1
SepsisD018805A41.9—1———1
Septic shockD012772A48.3—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSEVOFLURANE
INNsevoflurane
Description
Sevoflurane is an ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups. It has a role as an inhalation anaesthetic, a platelet aggregation inhibitor and a central nervous system depressant. It is an organofluorine compound and an ether. It is functionally related to a 2-methoxypropane.
Classification
Small molecule
Drug classgeneral inhalation anesthetics (halogenated alkane derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
FCOC(C(F)(F)F)C(F)(F)F
Identifiers
PDB—
CAS-ID28523-86-6
RxCUI36453
ChEMBL IDCHEMBL1200694
ChEBI ID9130
PubChem CID5206
DrugBankDB01236
UNII ID38LVP0K73A (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
Identifier
Target mutation
Effect
Evaluation
Status
VCV000575733CACNA1S, 520C>T, Arg174Trpdrug response2021-03-241A
VCV000017626CACNA1S, 3257G>A, Arg1086Hisdrug response2021-03-241A
VCV000012984RYR1, 14545G>A, Val4849Iledrug response2021-03-241A
VCV000012972RYR1, 7373G>A, Arg2458Hisdrug response2021-03-241A
Financial
Sevoflurane - AbbVie
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 23,596 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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13 adverse events reported
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