Silibinin
Silibinin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Therapeutic Areas
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Trade Name
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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Indications
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Agency Specific
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
20 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | 1 | 1 | — | — | 1 |
| Depression | D003863 | F33.9 | — | — | 1 | — | — | 1 | |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | 1 | — | — | 1 | 2 | ||
| Hepatitis c | D006526 | B19.2 | — | 2 | — | — | — | 2 | |
| Recurrence | D012008 | — | 2 | — | — | — | 2 | ||
| Diabetic nephropathies | D003928 | EFO_0000401 | — | 2 | — | — | — | 2 | |
| Proteinuria | D011507 | HP_0000093 | R80 | — | 2 | — | — | — | 2 |
| Oxidative stress | D018384 | EFO_1001905 | — | 2 | — | — | — | 2 | |
| Hiv | D006678 | O98.7 | — | 1 | — | — | — | 1 | |
| Liver failure | D017093 | HP_0001399 | K72.9 | — | 1 | — | — | — | 1 |
| Poisoning | D011041 | EFO_0008546 | T65.91 | — | 1 | — | — | — | 1 |
| Mushroom poisoning | D009145 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Smoking | D012907 | EFO_0003768 | F17 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 | ||
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypercholesterolemia | D006937 | HP_0003124 | — | — | — | — | 1 | 1 | |
| Overweight | D050177 | E66.3 | — | — | — | — | 1 | 1 | |
| Hypertriglyceridemia | D015228 | EFO_0004211 | — | — | — | — | 1 | 1 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 1 | 1 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | SILIBININ |
| INN | silibinin |
| Description | Silibinin is a flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities. It has a role as an antioxidant, an antineoplastic agent, a hepatoprotective agent and a plant metabolite. It is a flavonolignan, a polyphenol, an aromatic ether, a benzodioxine and a secondary alpha-hydroxy ketone. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc(C2Oc3cc(C4Oc5cc(O)cc(O)c5C(=O)C4O)ccc3OC2CO)ccc1O |
Identifiers
| PDB | — |
| CAS-ID | 22888-70-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1401508 |
| ChEBI ID | — |
| PubChem CID | 31553 |
| DrugBank | DB09298 |
| UNII ID | 4RKY41TBTF (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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9 adverse events reported
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