Skip to content
Silmitasertib
Silmitasertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against casein kinase II subunit alpha' and casein kinase II subunit alpha. In addition, it is known to target death-associated protein kinase 3, homeodomain-interacting protein kinase 3, and serine/threonine-protein kinase pim-1.
Download report
Favorite
Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
8 clinical trials
View more details
Mock data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CoronavirusD017934—1———1
Covid-19D000086382U07.1—1———1
MedulloblastomaD00852711———1
CholangiocarcinomaD018281C22.111———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple myelomaD009101C90.02————2
Basal cell neoplasmsD0182951————1
Breast neoplasmsD001943EFO_0003869C501————1
NeoplasmsD009369C801————1
Castleman diseaseD005871EFO_1001332D47.Z21————1
Inflammatory breast neoplasmsD0589221————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameSILMITASERTIB
INNsilmitasertib
Description
Silmitasertib (INN), codenamed CX-4945, is a small-molecule inhibitor of protein kinase CK2 (casein kinase II), a constitutively active serine/threonine-specific protein kinase that is overexpressed in several types of tumors.
Classification
Small molecule
Drug classserine/threonine kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12
Identifiers
PDB—
CAS-ID1009820-21-6
RxCUI—
ChEMBL IDCHEMBL1230165
ChEBI ID—
PubChem CID24748573
DrugBankDB15408
UNII IDC6RWP0N0L2 (ChemIDplus, GSRS)
Target
Agency Approved
CSNK2A2
CSNK2A2
CSNK2A1
CSNK2A1
Organism
Homo sapiens
Gene name
CSNK2A2
Gene synonyms
CK2A2
NCBI Gene ID
1459
Protein name
casein kinase II subunit alpha'
Protein synonyms
casein kinase 2 alpha', casein kinase 2, alpha prime polypeptide, CK II alpha'
Uniprot ID
P19784
Mouse ortholog
Csnk2a2 (13000)
casein kinase II subunit alpha' (O54833)
Alternate
DAPK3
DAPK3
HIPK3
HIPK3
PIM1
PIM1
Organism
Homo sapiens
Gene name
DAPK3
Gene synonyms
ZIPK
NCBI Gene ID
1613
Protein name
death-associated protein kinase 3
Protein synonyms
DAP kinase 3, DAP-like kinase, Dlk, MYPT1 kinase, ZIP-kinase, Zipper-interacting protein kinase
Uniprot ID
Q05JY4
Mouse ortholog
Dapk3 (13144)
death-associated protein kinase 3 (O54784)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Additional graphs summarizing 348 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
7 adverse events reported
View more details