Simtuzumab
Simtuzumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against lysyl oxidase homolog 2.
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Therapeutic Areas
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Trade Name
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Indications
FDA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Idiopathic pulmonary fibrosis | D054990 | J84.112 | 1 | 2 | — | — | — | 3 | |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 2 | — | — | — | 2 |
| Colorectal neoplasms | D015179 | — | 1 | — | — | — | 1 | ||
| Primary myelofibrosis | D055728 | D47.4 | — | 1 | — | — | — | 1 | |
| Hiv | D006678 | O98.7 | — | 1 | — | — | — | 1 | |
| Hepatitis c | D006526 | B19.2 | — | 1 | — | — | — | 1 | |
| Coinfection | D060085 | — | 1 | — | — | — | 1 | ||
| Sclerosing cholangitis | D015209 | EFO_0004268 | K83.01 | — | 1 | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 1 | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | SIMTUZUMAB |
| INN | simtuzumab |
| Description | Simtuzumab (humanized mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 1318075-13-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2109667 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB12152 |
| UNII ID | 11Z5AIU653 (ChemIDplus, GSRS) |
Target
Agency Approved
LOXL2
LOXL2
Organism
Homo sapiens
Gene name
LOXL2
Gene synonyms
NCBI Gene ID
Protein name
lysyl oxidase homolog 2
Protein synonyms
lysyl oxidase related 2, lysyl oxidase-like 2 delta e13, lysyl oxidase-like 2 protein, Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14
Uniprot ID
Mouse ortholog
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 531 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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31 adverse events reported
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