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Sivelestat
Sivelestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against neutrophil elastase.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
10 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Respiratory distress syndromeD012128EFO_1000637J8011—113
Acute lung injuryD055371EFO_000461011—1—2
Systemic inflammatory response syndromeD018746EFO_1001478R65.10———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Esophageal neoplasmsD004938C15————11
InflammationD007249————11
Respiratory insufficiencyD012131HP_0002093J96.9————11
Aortic dissectionD000784I71.0————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSIVELESTAT
INNsivelestat
Description
Sivelestat is a N-acylglycine and a pivalate ester. It is functionally related to a N-benzoylglycine.
Classification
Small molecule
Drug classenzyme inhibitors: elastase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)(C)C(=O)Oc1ccc(S(=O)(=O)Nc2ccccc2C(=O)NCC(=O)O)cc1
Identifiers
PDB—
CAS-ID127373-66-4
RxCUI—
ChEMBL IDCHEMBL76688
ChEBI ID—
PubChem CID107706
DrugBankDB12863
UNII IDDWI62G0P59 (ChemIDplus, GSRS)
Target
Agency Approved
ELANE
ELANE
Organism
Homo sapiens
Gene name
ELANE
Gene synonyms
ELA2
NCBI Gene ID
1991
Protein name
neutrophil elastase
Protein synonyms
Bone marrow serine protease, elastase 2, neutrophil, Elastase-2, granulocyte-derived elastase, HLE, Human leukocyte elastase, leukocyte elastase, Medullasin, PMN elastase, polymorphonuclear elastase, polymorphonuclear leukocyte elastase
Uniprot ID
Q6LDP5
Mouse ortholog
Elane (50701)
neutrophil elastase (Q61515)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 980 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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38 adverse events reported
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