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Sobetirome
Sobetirome is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target thyroid hormone receptor alpha and thyroid hormone receptor beta.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AdrenoleukodystrophyD000326Orphanet_43E71.5221———2
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSOBETIROME
INNsobetirome
Description
Sobetirome is a diarylmethane.
Classification
Small molecule
Drug classantihyperlipidemic, thyromimetic derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1cc(OCC(=O)O)cc(C)c1Cc1ccc(O)c(C(C)C)c1
Identifiers
PDB—
CAS-ID211110-63-3
RxCUI—
ChEMBL IDCHEMBL107400
ChEBI ID79988
PubChem CID—
DrugBank—
UNII IDXQ31741E9Q (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
THRA
THRA
THRB
THRB
Organism
Homo sapiens
Gene name
THRA
Gene synonyms
EAR7, ERBA1, NR1A1, THRA1, THRA2
NCBI Gene ID
7067
Protein name
thyroid hormone receptor alpha
Protein synonyms
c-erbA protooncogene, c-erbA-1, c-erbA-alpha, EAR-7, ERBA-related 7, Nuclear receptor subfamily 1 group A member 1, thyroid hormone receptor alpha 1, thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), triiodothyronine receptor, V-erbA-related protein 7
Uniprot ID
P10827
Mouse ortholog
Thra (21833)
thyroid hormone receptor alpha (Q99146)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 145 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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