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Sorbinil
Sorbinil is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target aldo-keto reductase family 1 member B1 and aldo-keto reductase family 1 member B10.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
1 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes mellitusD003920EFO_0000400E08-E13——1——1
Diabetic retinopathyD003930EFO_0003770——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameSORBINIL
INNsorbinil
Description
Sorbinil is an azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring. It has a role as an EC 1.1.1.21 (aldehyde reductase) inhibitor and an antioxidant. It is an imidazolidinone, a member of chromanes, an oxaspiro compound, an azaspiro compound and an organofluorine compound.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
O=C1NC(=O)[C@@]2(CCOc3ccc(F)cc32)N1
Identifiers
PDB4GA8
CAS-ID68367-52-2
RxCUI—
ChEMBL IDCHEMBL266497
ChEBI ID102029
PubChem CID337359
DrugBankDB02712
UNII IDG4186B906P (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
AKR1B1
AKR1B1
AKR1B10
AKR1B10
Organism
Homo sapiens
Gene name
AKR1B1
Gene synonyms
ALDR1, ALR2
NCBI Gene ID
231
Protein name
aldo-keto reductase family 1 member B1
Protein synonyms
Aldehyde reductase, aldehyde reductase 1, Aldose reductase, AR, Lii5-2 CTCL tumor antigen, low Km aldose reductase
Uniprot ID
Q9UCI9
Mouse ortholog
Akr1b1 (11677)
aldo-keto reductase family 1 member B1 (Q99KC9)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 546 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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