Soticlestat
Soticlestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cholesterol 24-hydroxylase.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
20 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myoclonic epilepsies | D004831 | EFO_1001900 | G40.4 | — | 2 | 2 | — | — | 4 |
| Lennox gastaut syndrome | D065768 | G40.81 | — | 2 | 2 | — | — | 4 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Epilepsy | D004827 | EFO_0000474 | G40.9 | 2 | 2 | — | — | — | 4 |
| Complex regional pain syndromes | D020918 | EFO_1001998 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 10 | — | — | — | — | 10 | ||
| Hepatic insufficiency | D048550 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | SOTICLESTAT |
| INN | soticlestat |
| Description | Soticlestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target cholesterol 24-hydroxylase. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O=C(c1cccnc1-c1ccncc1)N1CCC(O)(Cc2ccccc2)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 1429505-03-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4298172 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 1766MU795L (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CYP46A1
CYP46A1
Organism
Homo sapiens
Gene name
CYP46A1
Gene synonyms
CYP46
NCBI Gene ID
Protein name
cholesterol 24-hydroxylase
Protein synonyms
CH24H, Cholesterol 24-monooxygenase, Cholesterol 24S-hydroxylase, Cytochrome P450 46A1, cytochrome P450, family 46, subfamily A, polypeptide 1, cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
Uniprot ID
Mouse ortholog
Cyp46a1 (13116)
cholesterol 24-hydroxylase (Q9WVK8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 41 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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